ID A0A218V048_9PASE Unreviewed; 962 AA.
AC A0A218V048;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO4 {ECO:0000313|EMBL:OWK59268.1};
GN ORFNames=RLOC_00007848 {ECO:0000313|EMBL:OWK59268.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK59268.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK59268.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK59268.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK59268.1}.
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DR EMBL; MUZQ01000080; OWK59268.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218V048; -.
DR STRING; 299123.ENSLSDP00000001055; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF28; ANOCTAMIN-4; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 357..383
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 433..452
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 509..535
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 555..576
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 604..625
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 724..746
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 774..798
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 118..343
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 346..927
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 926..960
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 962 AA; 112343 MW; 95FC092CC19EF57D CRC64;
MEASSSGSTI SSVTGRKAKT HQPEGREDLQ VNQLETQIWI KPDIQKTDVD FSEILNAIQE
IAKDVNIFFD ELEGVNSPSK DDDSLLHHGN LTSTSDDASR LEVVGEEVPD KNKTNGLYFR
DGKCRIDYIL VYRKSNPQTE KREVFERNIR AEGLQMEKES SLTNSDIMFV KLHAPWEVLG
KYAELMNVRM PFRRKIYYLH RRYKFMNRIE KQISRFRGWL PRKPMKLDKE TLPDLEENDC
YTAPFSQQRI HHFIIHNKDT FFNNATRSRI VHHILQRVKY EEGKNKIGLN RLLSNGSYEA
AFPLHEGSYR SKNSIKTHGA ENHRHLLYEC WASWGVWYKY QPLDLVRRYF GEKIGLYFAW
LGWYTGMLFP AAFIGLFVFL YGVTTLNHCQ VSKEVCQATD IIMCPICDKY CPFMRLSDSC
IYAKVTHLFD NGATVFFAVF MAVWATVFLE FWKRRRAVIA YDWDLIDWEE EEEEIRPQFE
AKYSKKERMN PISGKPEPYQ AFADKCSRLI VSASGIFFMI CVVIAAVFGI VIYRVVTVST
FAAFKWALIR NNSQVATTGT AVCINFCIIM LLNVLYEKVA LFLTNLEQPR TESEWENSFT
LKMFLFQFVN LNSSTFYIAF FLGRFTGHPG AYLRLINRWR LEECHPSGCL IDLCMQMGII
MVLKQTWNNF MELGYPLIQN WWTRRKLRQE YGTQGKTSFP QWEKDYNLQP MNAYGLFDEY
LEMILQFGFT TIFVAAFPLA PLLALLNNII EIRLDAYKFV TQWRRPLASR AKDIGIWYGI
LEGIGILSVI TNAFVIAVTS DFIPRLVYAY KYGPCAGQGE AGQKCMIGYV NASLSVFLVS
DFENRSEPTS NGSEFSGSPL KYCRYRDYRD PPHSPVPYGY TLQFWHVLAA RLAFIIVFEH
LVFCIKHLIS YLIPDLPKDL RDRMRREKYL IQEMMYEAEL ERLQKERKER KKNGKSYHNE
WP
//
