ID A0A218V094_9PASE Unreviewed; 1068 AA.
AC A0A218V094;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Guanylyl cyclase C {ECO:0000256|ARBA:ARBA00039999};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
DE AltName: Full=Heat-stable enterotoxin receptor {ECO:0000256|ARBA:ARBA00042221};
DE AltName: Full=Intestinal guanylate cyclase {ECO:0000256|ARBA:ARBA00042330};
GN Name=GUCY2C {ECO:0000313|EMBL:OWK59336.1};
GN ORFNames=RLOC_00007902 {ECO:0000313|EMBL:OWK59336.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK59336.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK59336.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK59336.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00036920};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13666;
CC Evidence={ECO:0000256|ARBA:ARBA00036920};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK59336.1}.
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DR EMBL; MUZQ01000080; OWK59336.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218V094; -.
DR STRING; 299123.ENSLSDP00000002764; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF347; GUANYLYL CYCLASE C; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000313|EMBL:OWK59336.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1068
FT /note="Guanylyl cyclase C"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012690960"
FT TRANSMEM 434..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 492..752
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 827..930
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1068 AA; 123295 MW; B9BEC8A5C222524C CRC64;
MKELVLVLAV WPLFSSLQLL KKVASNRCSN NSYVINVMLM NYSDFPLSTD SLKLAVKQAL
DRVQKEFQMT GENVTVDAIF HPFTSSFYVS QACRTSTCEG VELIKTIYDS GTLGCAVIGP
ACTYATYQMV SLETILSLPL ISVGSFGLSC DYKENLTRLL TPARKLNQFF YHFWRHSGLP
FKTTTWESVY IYKRTETSEA CLWYMNALDA GITEFSEKLK FKDILRTPEL LKKTVKNPNR
KSNVIIMCGS PEDIGSDLGT EKVDNDIVII LIDLFNNVYF KKNISADYMH NVLVLTLPPA
NYSYNTVIKD YIEMEDNILM EDDFLAGYFN AVLLFGYSVK KFVVSQSPMS PFNLIHEFRN
TTFEGVVGPV TLDEFGDIDT NLTVLYTSQT ANYFKPLLYF NTQSNDTCKA TNSPDFIWKN
HKLPSDTPGT GPHILTIAVF TLTGIVILVL IISLLILRKY RRDNERRWKK WSHIPPEEIL
PLETNETSQI SLKIDEDKRR DTTQRLRQGK YDKKVVILKD LKNSDGNFSE KQKIELNKLL
QIDYYNLTKF YGTVKIDTMI FGVIEYCERG SLRDVLNDKI SYPDGTFMDW EFKISVMYDI
AKGMSYLHSS KTEVHGRLKS TNCVVDNRMV VKITDFGCNS ILPPRKDLWT APEHLRHADV
SQKGDVYGYG IIAQEIILRR ETFYTKHCWD NREKLYRVER GKGVKPFRPD LTLEIVGEKQ
MEVYTLVKSC WEEDPEKRPD FKKIESTLAK IFSNFHGQTN ESYMDTLIRR LQLYSRNLEH
LVEERTELYK AERDRADRLN FMLLPRPVVK SLKETGLVEP ELFEEVTIYF SDIVGFTTLC
KYSTPMEVVD MLNDIYKNFD HILDHHDVYK VETIGDAYMV VSGLPKRNGN RHAVDISMMA
LDILSFMGSF ELRHLPGLPV WIRIGIHSGT QSMCSWCGWN KNASLLFVWR YSKHSFADGI
HRLALRFHCL FIFLALRIHV SGSTINILKR TDCQFHYEER GETYLKSLFT KENQQRLHDD
LAEMITNSLQ KRENEGSKAQ ELSRVGSQRS GTLEYLQLVS TENFTTYV
//
