ID A0A218V0E9_9PASE Unreviewed; 1337 AA.
AC A0A218V0E9;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Vascular endothelial growth factor receptor 3 {ECO:0000313|EMBL:OWK59497.1};
GN Name=FLT4 {ECO:0000313|EMBL:OWK59497.1};
GN ORFNames=RLOC_00006707 {ECO:0000313|EMBL:OWK59497.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK59497.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK59497.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK59497.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK59497.1}.
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DR EMBL; MUZQ01000076; OWK59497.1; -; Genomic_DNA.
DR STRING; 299123.ENSLSDP00000013485; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05863; IgI_VEGFR-3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR041348; VEGFR-2_TMD.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF28; HEMICENTIN-2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 3.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR Pfam; PF21339; VEGFR-1-like_Ig-like; 1.
DR Pfam; PF17988; VEGFR-2_TMD; 1.
DR PRINTS; PR01832; VEGFRECEPTOR.
DR PRINTS; PR01835; VEGFRECEPTR3.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:OWK59497.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 839..863
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..175
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 304..385
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 390..473
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 480..616
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 619..734
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 741..827
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1145..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1260..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1269..1305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1337 AA; 151308 MW; 560C400BED5D61BA CRC64;
MQGCVQAGVF HRVRCVCAVV ESVFVCIPPL REAANVHPGT DKKQAMYGQS LTSAGVRTDL
VSSYSMTPPT LSITKEEHVI NAKDTLTITC RGQHPLEWSW PGGKVDPAGK EETELVASAA
PSSGWAIQEE DCEGTGTKPY CKVLVLTEAQ ANHTGYYRCY YKYIDAKVEG TTAVSTYVFV
RDFEQPFINK PETLLISNKE NTWVPCLVSI PDLNVTLTSV RAWLLGDCTE QNFFIHPDGK
STLWDNKKGM QVPTHLIRDL LYVHCETVID KKVFKSNFFI IHIAGSELYD IQLYPKKAME
LLVGEKLVLN CTVWAEFNSA VGFHWTYPGK QTQRALIESE RRSLQTQTEL SSILTLHNVS
QQDLGKYTCT ATSDAQMLEE STDVIVHEKP FITVEWRKGP VIEATAGDEA VKLPVKVVAY
PPPDFQWYKD GKLIPKQSQS SMQIKDVSEQ HAGTYTLVLR NRLAGLEKHI SLQLIVNVPP
RIHEKEASSP SIYSKRSPQA LTCTVYGIPA PEVIQWQWRP WMPCRMFSRR SLNSRHRAAR
RHQRDRMPEC KDWKDVSQQD AVNPIESIDT WVEFVEGRNK TVSKLAIQEA NVSAMYKCIA
SNKVGRDERL IYFYVTTIPD GFEIESQPSE EPIEGQDLQL SCNADNYTYE NLQWYRLNLS
KLHDEEGNPL VLDCKNVHHY ATKMQGDLRF QPNSNDATLL LTIPNISLDE EGDYVCEVQN
RKTREKHCHK KYISVQALEI PRLKQNLTDI WVNVSDSIEM RCKVDGNHVP EISWYKDEKL
VEEVSGIDLA DFNQRLSIQR VREEDAGLYL CSVCNAKGCV NSSASVSVEG SDDRTNVEIV
ILIGTGVIAV FFWILLILIF CNIKRPAHAD IKTGYLSIIM DPGEVPLEEQ CEYLPYDSSK
WEFPRDRLRL GPLMVIVEFC KYGNLSNYLR TKREGFSPYR EKSPRLRIQV QSIVEAVRAD
RRSRSGTSDS AIFQRFLLHK SRTALPIQEV DDLWQSPLTM EDLICYSFQV ARGMEFLASR
KRPDYSHFSG ASPYPGVQIN EEFCQRLKDG TRMRAPEYAT AEIYRIMLSC WHGDPKERPT
FSDLVEILGN LLQENVQQVK ACCPFSAPDS SFSVITSSLT VPSADPMAIY CSSYQEGKDY
IPLNDSHSSE DDGFSQVPSS AQQNSDEEDF DMRIRCHSLA ARYYNCVSFP GCLTGGNQIR
CPSRIKTFEE FPMTHTMYKA HPSTGMLLII PVASFQDNQT DSGMVLASEE FERIENRHRK
EGGFSSKGPS RTMELSGEQS ELQGRYRPSY GSQVGGQTFY NSEYGELSEH SEDGSCTPPG
EGASPPTLHA SFFSEQY
//
