ID A0A218V2T0_9PASE Unreviewed; 436 AA.
AC A0A218V2T0;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Adenosine receptor A2 {ECO:0000256|RuleBase:RU201114};
GN Name=ADORA2A {ECO:0000313|EMBL:OWK60239.1};
GN ORFNames=RLOC_00008790 {ECO:0000313|EMBL:OWK60239.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK60239.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK60239.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK60239.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is
CC mediated by G proteins which activate adenylyl cyclase.
CC {ECO:0000256|RuleBase:RU201114}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU201114}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU201114}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU201114}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK60239.1}.
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DR EMBL; MUZQ01000064; OWK60239.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218V2T0; -.
DR STRING; 299123.ENSLSDP00000012698; -.
DR OrthoDB; 2909020at2759; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001609; F:G protein-coupled adenosine receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001513; Adeno_A2A_rcpt.
DR InterPro; IPR001634; Adenosn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24246:SF47; ADENOSINE RECEPTOR A2A; 1.
DR PANTHER; PTHR24246; OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00553; ADENOSINA2AR.
DR PRINTS; PR00424; ADENOSINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU201114};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU201114};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU201114};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW ECO:0000256|RuleBase:RU201114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU201114};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU201114};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU201114};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU201114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU201114}.
FT TRANSMEM 13..38
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 50..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 78..106
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 127..149
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 187..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 244..267
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT DOMAIN 29..297
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 436 AA; 48513 MW; DA94055E94609EA1 CRC64;
MLVHGKDDFL SDIAYIILEL IIAVLAILGN ILVCWAVYLN SNLQNVTNYF VVSLAAADIA
VGVLAIPFAI TISTGFCAFF YGCLFIACFV LVLTQSSIFS LLAIAIDRII AIRIPLRYNG
LVTGSRAKGI IAICWVLSFI IGLTPMLGWH KRAQIEELGS NWSSPINCSN SMVACLFEAV
VTMEYMVYYN FFACVLLPLL LMFGIYLKIF MAARRQLKQM ENKMVHGERS RSTLQKEVHA
AKSLAIIVGL FAVCWLPLHI INCFTLFCPN CAHAPLWLMY LAIILSHANS VVNPLIYAYR
IREFRHTFRK IISQHILGRK EPFKAGAASS RTSTHGGDAE NASIRISEYA LEVYTNGEIH
RDPEKQDLNK CKAGLEWHQN GNALDLETNG HLPHSCKNGI LSDACLNREL HSEELIDAQV
SYSDLERAAF AAADVS
//
