ID A0A218V7D1_9PASE Unreviewed; 471 AA.
AC A0A218V7D1;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Phosphatidylinositol 3-kinase catalytic subunit type 3 {ECO:0000313|EMBL:OWK62025.1};
GN Name=PIK3C3 {ECO:0000313|EMBL:OWK62025.1};
GN ORFNames=RLOC_00001530 {ECO:0000313|EMBL:OWK62025.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK62025.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK62025.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK62025.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00880}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK62025.1}.
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DR EMBL; MUZQ01000032; OWK62025.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218V7D1; -.
DR STRING; 299123.ENSLSDP00000025277; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd08397; C2_PI3K_class_III; 1.
DR CDD; cd00870; PI3Ka_III; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF7; PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR SMART; SM00142; PI3K_C2; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:OWK62025.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Transferase {ECO:0000313|EMBL:OWK62025.1}.
FT DOMAIN 35..186
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 283..471
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT REGION 150..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 54020 MW; D9D6E91FC304B7E2 CRC64;
MGETERLYYV YSCDLDINVQ LKIGSLEGKR EQKSYKALLE DPMLKFSGLY QETCSDLYVT
CQVFAEGKPL ALPIRTSYKA FSTRWNWNEW LKLPVKYPDL PRNAQVALTI WDVYGPGKAV
PVGGTTVSLF GKYGMFRQGM HDLKVWPNVE ADGSEPTKTP GRTSSTVSED QMSRLAKLTK
SHRQGHMVKV DWLDRLTFRE IEMINEREKR SSNFMYLMIE FRCVKCDDKE YGIVYYEKDG
DESSPVLTSP EIVKIPDPQM SMENLVESKH HKLARSLRSG PSDHDLKPNA TTRDQLNIIV
SYPPTKQLTY EEQDLVWKFR YYLTHQEKAL TKFLKCVNWD LPQEAKQALE LLGKWKPMDV
EDSLELLSSH FTNPTVRRYA VARLQQADDE DLLMYLLQLV QALKYENFDD IKNGLEPSKR
DSQGSMSETM TTSGSNAPEI DSSQIMSPIP PVSSPPLTSK TKELAENENL D
//
