ID A0A218V8L9_9PASE Unreviewed; 2667 AA.
AC A0A218V8L9;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Fibrillin-1 {ECO:0000313|EMBL:OWK62100.1};
GN Name=FBN1 {ECO:0000313|EMBL:OWK62100.1};
GN ORFNames=RLOC_00012476 {ECO:0000313|EMBL:OWK62100.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK62100.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK62100.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK62100.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK62100.1}.
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DR EMBL; MUZQ01000030; OWK62100.1; -; Genomic_DNA.
DR STRING; 299123.ENSLSDP00000024358; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0001527; C:microfibril; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 28.
DR Gene3D; 2.10.25.10; Laminin; 41.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 8.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF2; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 5.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 29.
DR Pfam; PF21364; FBN_EGF_st1; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF00683; TB; 7.
DR PIRSF; PIRSF036312; Fibrillin; 6.
DR SMART; SM00181; EGF; 42.
DR SMART; SM00179; EGF_CA; 39.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 9.
DR SUPFAM; SSF57581; TB module/8-cys domain; 7.
DR PROSITE; PS00010; ASX_HYDROXYL; 35.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 25.
DR PROSITE; PS50026; EGF_3; 35.
DR PROSITE; PS01187; EGF_CA; 16.
DR PROSITE; PS51364; TB; 8.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2667
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013256584"
FT DOMAIN 147..179
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 185..228
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 247..288
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 289..330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..390
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 443..483
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 484..523
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 600..640
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 641..681
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 687..733
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 733..774
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 775..816
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 817..856
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 857..898
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 903..954
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 974..1015
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1016..1058
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1059..1100
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1101..1142
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1184..1225
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1226..1266
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1267..1305
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1308..1349
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1350..1386
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1391..1431
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1436..1498
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1487..1528
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1529..1565
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1574..1614
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1632..1673
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1674..1714
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1766..1801
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1805..1847
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1848..1887
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1888..1929
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1934..1986
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2002..2038
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2041..2080
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2166..2203
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2212..2265
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2277..2318
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2360..2402
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2403..2439
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 29..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2522..2544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 151..161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 169..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 488..498
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 821..831
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1770..1780
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2667 AA; 290420 MW; 321ED43B26F39236 CRC64;
MWRGRLLGIA LGVAVLWASQ AGAAAAGHAE GVSAKESRSS RAKRRGHGGG HDALKGPNVC
GSRYNAYCCP GWKTLPGGNQ CIVPICRHSC GDGFCSRPNM CTCPNGQIAP SCGSKSIQHC
NIRCMNGGSC SDDHCLCQKG YTGTHCGQPV CENGCLNGGR CVAPNRCACT YGFTGPQCER
DYRTGPCFTL VTNQMCQGQL SGIVCTKTLC CATVGRAWGH PCEMCPAQPH PCRRGFIPNI
RTGACQDVDE CQAIPGICQG GNCINTVGSF ECKCPAGHKF NEVTQKCDDI DECSTIPGIC
DGGECSNTVS SYFCKCPPGF YTAPDGLKCI DVRPGFCFST LSNGRCGNQL PQPLSKMQCC
CDSGRCWASA PATAPEMCPI RSTDEYRKLC TVAAMLPARP DLPPVRPDII PPPHIPDVYP
PPHPEIIYPS RAPPVHPILP VNLTDYCQAF RHLCRNGRCI PTPGSYRCEC NKGFQLHGRE
ECLDIDECER NPCIGGDCVN TQGSYICQCR VGYQSTATRT ECRESPVCRN LWEMVQALME
NTEQSEKCLD SLSQHLVSPL LEERESCQPR VISLFRSSKA LAKHLLQREG NEDLMFQIQN
MDECSIRNIC LNGMCINEDG SFKCICKPGF QLASDGRYCT DINECETDGI CMNGRCVNTD
GSFRCECFPG LAVGLDGRVC VDTHMRSTCY GGYKRGQCVR PLTGAVTKSE CCCASTDYAF
GEPCQPCPAQ NSDINECLLD PDLCPNGRCE NLHGTYKCYC DPGYEVDSTG KNCIDIDECA
LNMLLCDNGQ CRNTPGSFTC TCPKGFVYTP DLKTCEDIDE CESNPCVNGV CKNTPGSFVC
ECSPESTLDP TRTICIDVNE CEVFPGVCTN GQCVNTLGSF VCQCPSGMTL DASGRTCLDI
RLESCYLQHE DEQCTSQIPG RHRMDACCCS VGAAWGQECE ECPLRGTPEF EALCPRGPGF
STKIEISGKP FSKDINECKM FPSLCTHGKC RNTIGSFKCR CDSGFALDSE ERNCTDINEC
HISPDLCGQG RCINTPGDFK CECFEGYESG FMMMKNCMDI DECQRNPLLC RGGTCINTEG
SFRCDCPPGH QISPNISACV DINECELSTN LCRNGRCVNL IGKYQCACNP GYQSTQDKLY
CIDIDECKIM NGGCEDFCTN SEGSYECSCK QGFALMPDHR TCTDIDECED NPNICDGGQC
TNIPGEYRCL CYDGFMASED MKTCIDINEC EIGAHNCDRH AICTNTAGSF KCSCSPGWIG
DGIKCTDLDE CSNGTHMCSP HADCKNTMGS YRCLCKEGYT GDGFTCTDLD ECSENLNLCE
NGQCLNAPGG YRCECEMGFL PSVDGKACED IDECSLPNIC VYGTCHNLPG LFRCECEVGY
ELDRSGGNCT DVNECADPTT CISGTCINTA GSYTCECPPD FELNPTRVGC VDTRSGNCYL
DIKTRGDNGG TFCSNEIGVG VSKASCCCSL GKAWGVPCEH CPLVNTNIDE CQELPGLCQG
GKCINTFGSF QCQCPSGYYL NEETRVCDDV NECETPGICG PGTCYNTVGN YTCICPPDYM
QVNGGNNCMD MRRSLCYRNY YADNQTCDGE LLFNMTKKMC CCSYNIGHEF STLCGSQRPG
FFIDIYTGLP VDIDECREIP GVCENGICIN MVGSFRCECP VGFFYNDKLL ICEDIDECQN
GPVCQQNAEC VNTAGSYRCD CKPGYRFTST GRCAGFITGV QEEQGKIGMN AKKFPISAAM
GSVLTLLEVS TAFVTMDSKP MMTEQYINEC ERDACGNGTC RNTIGSFNCR CNLGFILSHN
NDCIDVDECA SGNGMLCRNG QCVNTIGSFQ CLCNDGYEVA VDGRTCVDIN ECALEPGKCS
PGTCQNLDGS FRCICPPGYI LQNDKCEDID ECVEQPEICA LGTCSNTPGS FKCLCPEGFV
LSSTGRRCQD LRVSYCFTKF EDGKCSVPKS RNHSKQECCC ALKGQGWGDP CELCPEEADE
AFRQICPFGI GILVGPGDAR LDVDECLDPD NCKFGQCINT DGSFRCECPY GYILQGAECV
DTDECAVGNP CGNGTCRNVI GGFECTCVEG FEPGPMMTCE DVNECIQNPL LCAFRCVNTF
GSYECKCPGG YVLREDRRMC RDQNECEEGI HDCDSKQMEC KNLIGTYMCI CGPGYQRRPD
GEGCIDENEC QTKPGLCENG RCLNTLGSYR CECNEGFTVS DTQDECLDNR EGYCFTEVLQ
SMCQIGSSNR NAVTKSECCC DGGRGWGQNC EVCPFPGTVA FKKLCPHGRG YTSSGADIDE
CKVIHDVCRN GECINERGTY HCLCNLGYTT DVTGTLCIDL NECNESPKPC NFICKNTEGS
YQCSCPKGYI LQEDGRSCKD NNECATEINL CGAKGICQNT PGSFVCECQR GFSLDQTGQS
CEDENECLSA HICGGASCHN TLGSYKCMCP TGFQYEQFSG GCQDINECGS AQAPCSYGCS
NTEGGYVCGC PPGYFRIGQG HCVSGVGLGR GQGQELSLSG EVDDNSLSPE ACYECKINGY
PKRGRKRRST NETASEAEDQ QELEPPISLA SWDIEKAAVF SINISDLSNK DRILELLPAL
TTLTNHNRYL IDSGNEDGFF RINKKDGISY LHFTKKKPVP GNYSLQISSI PLYKKKELNQ
LEAKHDKDYL SGELGDNLKM KIQILLH
//
