ID A0A218VAD4_9PASE Unreviewed; 1490 AA.
AC A0A218VAD4;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 {ECO:0000313|EMBL:OWK62710.1};
GN Name=ARAP1 {ECO:0000313|EMBL:OWK62710.1};
GN ORFNames=RLOC_00001221 {ECO:0000313|EMBL:OWK62710.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK62710.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK62710.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK62710.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK62710.1}.
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DR EMBL; MUZQ01000023; OWK62710.1; -; Genomic_DNA.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR CDD; cd13256; PH3_ARAP; 1.
DR CDD; cd17226; RA_ARAP1; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 2.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 5.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 9..68
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 291..383
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 405..494
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 491..618
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 701..808
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 819..910
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 914..1149
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1181..1270
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1283..1434
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 94..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1490 AA; 167832 MW; CD6245E5CC8EBBA5 CRC64;
MEEEGSLPVA AWLSALHLDQ YVESFQQSEL WSVWDCRALT DEGLTRLGVL LPGHRRRILL
GLQKAFAEAP LPAGAQQPPA TKPVPMKRHI FRPSAAAGPE QPEPRGLPGP AKRHQLETKC
QNLKGPPLPD RPPVLPPRAQ RSIPAKEEVP ITERAPGVTV SSLLPLPRTQ VPPTPPALPS
KATLPFVPEF DDSDYEDSAW ESEIARPTGE MAKEDAEPGM GRPRSVRFNS LFSEDEFGED
QPSASPASGG SSWSDRDPSL HPPAPDAFAG SSPGTLSDSM EGTSATSLLS PTIKAGWLDK
NPPQGSYIYQ KRWVKLDTDY LRYFDSEKDT YSKRLIPVSS ISRVSSVGDQ KFEVVTNNRN
FVFRAENDAD RNEWIWTLQQ IAEEQKSKAA ARTSMSLASD SATELADKSG FLELRGFKHK
LFVVVAGDKV FLYKNAEDYR LGIGITYIEM NVGNVKEVDR RGFDLTTPYR IFSFSADSEQ
EKEEWVEAMQ QSIIEALSNS EVAERIWAVE SNRFCADCGS PKPDWASINL CVVICKRCAA
KPPHMPQQYG HVGISLSLFS QLFQQFGNVM ANQFWAANVP PSEAISPTSG SQERRRFLIA
KYREGKYRHY HPLFGNQEEL DRALCAAVTT SDLAETQALL FCGASVTCDT GDPQCPTPLA
LAERSGQRLQ MEFLLHNKTS EPPRLEVMCS EEKPYSVHLP SITHNGFLYK TPSMVKPISE
RKGPEEFSRR WCTLQDGVLS YYENDRNTVP NGEIRVEEIV CLVNNPLHAH GIESTFEVYT
EADRLYLFGL ESPDSAREWL KSIAKSFVHP CAEELLALDF ERLGRLHYKG GLTLERAQEG
WFALVGSTLH ICSEDGRQQE PLQLRKLQEL SIQGDHEVLV LVERRRTLYI QGERKLDFLG
WVHAIQKAAS SSGDTLSEQQ LTDSDVPLLV DRCIDYITQC GLTSEGIYRK SGQNSKTTSL
LEVLQRDARC VCLKEGEHQV DDVANTLKRF FRDLGDGLFT RRWAPDWLWA TALEDEEAKV
GEYRQLLAAL PPVNRATLKA LINHLFRYGI DPLGMNLSTV GSLLALGCGK SLFLLLMFPA
RKGDEFGVKL CLMPSIIVSH RVQCFSAENQ MNTHNLAIVF GPTLFQTDGK DYKAGRVVED
LISHYVEIFN VNDQEMKKQQ DEITAIMKMR EASSSGTQQA GDFICTVYLE EKKTETEQHV
KIPATMTAEE LTFEILDRRK IVMKEKDYWS CFEVNEKEEA ERPLHYSEKV LPILHCLGTE
SYLVVKKQMS MENMLIYLAS RVGDCKHGLM KFREERNLLG LGLSTGFHDR YFILNHSWLR
LYKEVRSLRQ RSPPLESVNP IPATVGTVVS GDRSGSHQPS VGSLFPQSHK PEKEWPVRNL
KVYLGVKKKL RPPTCWGFTV FYENEKHEKQ QWYLCCDTQA DLREWFATFL QVQNGGALWP
SERPKMRVAR PQQDARLGNI SLIPLRGNES EMRNSVAAFA TDPLTLLRNV
//
