ID A0A218VAE5_9PASE Unreviewed; 740 AA.
AC A0A218VAE5;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN Name=TMTC4 {ECO:0000313|EMBL:OWK62899.1};
GN ORFNames=RLOC_00015194 {ECO:0000313|EMBL:OWK62899.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK62899.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK62899.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK62899.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK62899.1}.
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DR EMBL; MUZQ01000020; OWK62899.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218VAE5; -.
DR STRING; 299123.ENSLSDP00000025008; -.
DR OrthoDB; 155869at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44227; -; 1.
DR PANTHER; PTHR44227:SF3; PROTEIN O-MANNOSYL-TRANSFERASE TMTC4; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF13432; TPR_16; 2.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:OWK62899.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 292..364
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 480..513
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 514..547
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 582..615
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 684..717
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 740 AA; 83591 MW; DF6EE6BFAF18D924 CRC64;
MAQMEPNLDH DVSWFLLPSY WAKMVVALIS FLCFANSYDG DFVFDDSEAI INNKDLRAET
PLGDLWYHDF WGSKLSSNTS HKSYRPLTVL TFRINYLFAG GFYPVGFHVI NIILHCTISV
LMVDVFSILL GGLQFSSKGR RLNLAPKSSL LAALLFAVHP VHTECVAGIV GRADLLCALF
FLLSFLGYCK AFKESKEGHT FSVFWVLVSV VLGAIAMLCK EQGITILGLN AVFDALVINK
INLLELIRKL LYKDKSLENA GLLRKGLLFR MTLLMCGGAG ILYIRWRIMG TGPPAFTEVD
NPASFADSLF VRAINYNYYY SLNAWLLLCP WWLCFDWSMG CIPLIKSVSD WRIIALAALW
FCLIGLICQA LCSEDSHKRR ILTLGLGFLI IPFLPASNLF FRVGFVVAER VIYLPSIGYC
ILFTYGFCLL SKQAKKKKIL AVAVLGILLI NVMRCALRSS QWRSEEQLFR SALSVCPLNA
KVHYNVGKNL ADKGNQSAAI KYYREAVRLN PKYVHAMNNL GNILKERNEL HEAEELLSLA
VQIQPDFAAA WMNLGIVQNS LRRFEEAEQS YWTAIKHRKK YPDCYYNLGR LYADLNRHID
ALNAWRNATV LKPEHSLAWN NMIILLDNTG NLAQAEAVGR EALELIPNDH SLMFSLANVL
GKSQKYKESE ALFLKAIKAN PNAASYHGNL AVLYHRWGNL DLAKKHYEVS LKLDPMAPGT
KENYNLLRRK LEQLQKKGSA
//
