ID A0A218W9T2_PUNGR Unreviewed; 717 AA.
AC A0A218W9T2;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Nucleobase-ascorbate transporter 12 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CDL15_Pgr025158 {ECO:0000313|EMBL:OWM68971.1};
OS Punica granatum (Pomegranate).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Lythraceae; Punica.
OX NCBI_TaxID=22663 {ECO:0000313|EMBL:OWM68971.1, ECO:0000313|Proteomes:UP000197138};
RN [1] {ECO:0000313|Proteomes:UP000197138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Dabenzi {ECO:0000313|Proteomes:UP000197138};
RX PubMed=28654223; DOI=10.1111/tpj.13625;
RA Qin G., Xu C., Ming R., Tang H., Guyot R., Kramer E.M., Hu Y., Yi X.,
RA Qi Y., Xu X., Gao Z., Pan H., Jian J., Tian Y., Yue Z., Xu Y.;
RT "The pomegranate (Punica granatum L.) genome and the genomics of
RT punicalagin biosynthesis.";
RL Plant J. 91:1108-1128(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWM68971.1}.
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DR EMBL; MTKT01004939; OWM68971.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218W9T2; -.
DR Proteomes; UP000197138; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR11119:SF28; NUCLEOBASE-ASCORBATE TRANSPORTER 12; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 197..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 647..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 717 AA; 77260 MW; C87D078F8E8EB986 CRC64;
MSSSDPKARP KPGPWPPAPE SSAMPLSTWA KRTGFRPKFS GEANAGDSGQ MSQPPRPREP
DNQPDLEAGR ARPQPQPQPQ PAPVVVNGQA GGDKPAAALP PPPTANKEKD QPVKKRRDSD
GGAPKSSSPG ANRRAAPSSN EQPPPPRRPS RNGEVVDVVN QSTVDEDGFM GRPSHMKYEL
RDSPGLVPVG FFGFQHYLSM LGSLVLIPLV IVPAMGGKHE DVAAVVSTVL FVSGLTTLLH
TFFGSRLPLI QGPSFVYLAP VLAIINSPEF QGLKGNSFKH IMKEIQGAVI IASAFQAILG
YSGLMGLLLR FINPVVVSPT IAAVGLSFYS YGFPLVGNCL EIGIVQILLV IVFSLVPLGL
AISWAAAFLL TEAGLYNYKG CDINIPASNI VSEHCRKHIS RMKYCRVDTS QALKASPWFR
FPYPLQWGTP VFHWKLAIVM CVVSLIASVD SVSLSSYALY LHGAYVVISL VGSYHASALL
VASRPPTPGV LSRGIGLEGL SSILAGLWGT GTGSSTLTEN VHTIAVTKVG SRRAVEVGAC
VLILLSLVGK IGGFIASIPQ VMVAALLCFM WAMLTALGLS NLRYSEAGSS RNIIIVGLSL
FFSLSIPAYF QQYGISPNSN LSAPSYFQPY IVASHGPFRT PYRGLNYVMN TLLSLHMVIA
FLVAFMLDNT VPGSKQERGV YVWSEHEVAR REPAVAKDYE LPFRVSKFFR WVKWVGL
//
