ID A0A218XPA8_PUNGR Unreviewed; 373 AA.
AC A0A218XPA8;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 22-FEB-2023, entry version 12.
DE RecName: Full=ER membrane protein complex subunit 4 {ECO:0000256|ARBA:ARBA00020820};
GN ORFNames=CDL15_Pgr015853 {ECO:0000313|EMBL:OWM86817.1};
OS Punica granatum (Pomegranate).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Lythraceae; Punica.
OX NCBI_TaxID=22663 {ECO:0000313|EMBL:OWM86817.1, ECO:0000313|Proteomes:UP000197138};
RN [1] {ECO:0000313|Proteomes:UP000197138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Dabenzi {ECO:0000313|Proteomes:UP000197138};
RX PubMed=28654223; DOI=10.1111/tpj.13625;
RA Qin G., Xu C., Ming R., Tang H., Guyot R., Kramer E.M., Hu Y., Yi X.,
RA Qi Y., Xu X., Gao Z., Pan H., Jian J., Tian Y., Yue Z., Xu Y.;
RT "The pomegranate (Punica granatum L.) genome and the genomics of
RT punicalagin biosynthesis.";
RL Plant J. 91:1108-1128(2017).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the EMC4 family.
CC {ECO:0000256|ARBA:ARBA00007715}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWM86817.1}.
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DR EMBL; MTKT01001080; OWM86817.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218XPA8; -.
DR Proteomes; UP000197138; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR009445; TMEM85/Emc4.
DR PANTHER; PTHR19315; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR19315:SF9; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF06417; DUF1077; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 66..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 276..372
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|SMART:SM01117"
FT REGION 20..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 373 AA; 41313 MW; B1EEB7957ECD07C8 CRC64;
MEKGKGVMGF GRRWAVEFTD ASAAPSSRDD DSSVSRQKKD AEANWKSQKA WEVAQAPFKN
LMMMGFMMWM AGSTVHLFSI GITFSALWQP ISALQGVGKV FEPYKDSKVD LLAPKLLFIA
LNLGGLALGV WKLNTLGLLP THASDWVSSL PPAQHGKFSL KYGKIMSHCL SGPCRFQYEA
NFSRKIYVIL SAPGKLGLME MQPLHHVDLA FNIVKHAFFD RYHTLLQLQA FDRYYSLLWP
YATSTINYIY RTALPLSLTQ SPNCSSLSSS SAEMEFTAQQ LSLYNGTDPS KPIYVAIKGR
VFDVTAGKPF YGPGGAYAMF AGKDASRALA KMSKNEEDVT ACLDGLSEKE IGVLKDWETK
FEAKYPVVGR VVS
//
