ID   A0A218XQP0_PUNGR        Unreviewed;      1144 AA.
AC   A0A218XQP0;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=CDL15_Pgr010192 {ECO:0000313|EMBL:OWM87160.1};
OS   Punica granatum (Pomegranate).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Myrtales; Lythraceae; Punica.
OX   NCBI_TaxID=22663 {ECO:0000313|EMBL:OWM87160.1, ECO:0000313|Proteomes:UP000197138};
RN   [1] {ECO:0000313|Proteomes:UP000197138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Dabenzi {ECO:0000313|Proteomes:UP000197138};
RX   PubMed=28654223; DOI=10.1111/tpj.13625;
RA   Qin G., Xu C., Ming R., Tang H., Guyot R., Kramer E.M., Hu Y., Yi X.,
RA   Qi Y., Xu X., Gao Z., Pan H., Jian J., Tian Y., Yue Z., Xu Y.;
RT   "The pomegranate (Punica granatum L.) genome and the genomics of
RT   punicalagin biosynthesis.";
RL   Plant J. 91:1108-1128(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWM87160.1}.
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DR   EMBL; MTKT01000826; OWM87160.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A218XQP0; -.
DR   Proteomes; UP000197138; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR11017:SF580; DISEASE RESISTANCE-LIKE PROTEIN DSC1; 1.
DR   PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00369; LRR_TYP; 2.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          14..182
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1144 AA;  129774 MW;  C1C197DD21C3104F CRC64;
     MSSRLNISEE FETEECHVFL NFRGKDTRRG FINTLSAFFQ FKERNIRVFL DEKKIKVGNE
     IAERIKRAIT DSQIYICVFS RNYASSPWCL RELAFMLESR RKSNGKEILP IFYNVKVEDV
     KLKTDLYRDH LSELKKEYGE ETVQKWEKAL KEIAAIKGWD SADYGGDADL SEVVVGEVRS
     RLKIQQMRGH LVGLKEAIDN VIAKLDIESG GVKFLAIHGV SGVGKTSLAK SVFHQLSVRF
     QGCSFLADIQ ESFEHGNGFE ALKEQLLRDI PDSDGESTSI EKRFRDKKVL IVLDNVNKRE
     QVMEFAKKSL RFGPGSRIII TTAKDHPILL IQPAAGKKST EGAAKKFKEF DTLEMKEMEF
     DQALRLFSKY AFCKDSPPDD HRSLSEQAVE SVGPLIPLTI EIIGSFLRGK NEEVWNRTFL
     ELKEIHSHAI NLKLKVIYDA LSYQAKQIFL DIACLFVNKE KTNAMYTWEA CHNNREGIDV
     LTGMSMVKIL DDGKLWMHDY LRDLGRGIVD ADRWKNPGVL TRLWRHNEAL EVLQRYEGKQ
     NVEALCLCYD PSLRGLTLTH KEFTNLKVLR FLKLYSVKLS GDLEHLLPRL RWLSWHECPH
     EFEATNLLLR KLVILDLSES LIMDKWGGWS CLQGAIILKV LDLTGCRHLE RTPNLSKFKY
     LERMILAGCT RLVEIDSSIV EMKRLKYLNL RGCDSLMELP EQIGSLEALS EIIFMQGECK
     PFNLPESIGS SKSMSILEVG NVGISQLPLS KGGLGRLERL SLFRCSMIKQ LPDSLGGLSQ
     LIELDVSETG IIAFPASIGD LKELKVIKMS RCPITELPRA IGMAQNLKEL HADHCTELRG
     EVPAEIGNLS HLKILDLSYT GITTLPETIS QLSELEILHL ESCHNLERLP KLPQGLTRLH
     FELWSLLEDP ILCELGNLVD LVMSDIGPDL PSQGHISNLE WMQTLSKLEN LDLSVSDSST
     FCLPQLKSLN LSCRDLSKAC SELPCTLSRC SIKEKDGLEL GQLKSLFHFS AIECLFRMGK
     GLCLPKDLRV LSMSECEFCA DTFLDLAGLK HLKQLKLSKC KGLIEVRGVG QLESLQELIV
     RHCECLARLD DLSNLRKLEI VKIYDCEMLT YVGDLERISE LDLKEKFIFL NCRPVKGSCD
     EQSS
//