ID   A0A218XSN9_PUNGR        Unreviewed;       887 AA.
AC   A0A218XSN9;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=CDL15_Pgr022789 {ECO:0000313|EMBL:OWM87676.1};
OS   Punica granatum (Pomegranate).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Myrtales; Lythraceae; Punica.
OX   NCBI_TaxID=22663 {ECO:0000313|EMBL:OWM87676.1, ECO:0000313|Proteomes:UP000197138};
RN   [1] {ECO:0000313|Proteomes:UP000197138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Dabenzi {ECO:0000313|Proteomes:UP000197138};
RX   PubMed=28654223; DOI=10.1111/tpj.13625;
RA   Qin G., Xu C., Ming R., Tang H., Guyot R., Kramer E.M., Hu Y., Yi X.,
RA   Qi Y., Xu X., Gao Z., Pan H., Jian J., Tian Y., Yue Z., Xu Y.;
RT   "The pomegranate (Punica granatum L.) genome and the genomics of
RT   punicalagin biosynthesis.";
RL   Plant J. 91:1108-1128(2017).
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWM87676.1}.
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DR   EMBL; MTKT01000813; OWM87676.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A218XSN9; -.
DR   Proteomes; UP000197138; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 2.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 2.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          80..503
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
SQ   SEQUENCE   887 AA;  98555 MW;  7A76512BF4F88BFF CRC64;
     MAFTSTLRFS SLLLRSRFTA PLCPVRFSWR LSELRFYSVP SSRVLRARRR EGPIKAEQGG
     NGSVVVKDKD GNNGERIMPA ELHKEATDAY MAYAMSVLLG RALPDVRDGL KPVHRRILFA
     MHELGLSSRK PFKKCARVVG EVLGKFHPHG DTAVYDSLVR MAQGFSLRCP LIQGHGNFGS
     VDADPPAAMR YTECRLEALT EAVLLADIDQ KTVDFVPNFD NSQMEPSLLP ARLPTLLLNG
     SSGIALQELL EYMPGPDFPT GGLIMGNMGI LEAYRTGRGR IVVRGKTDIE LLDSKSKRTA
     IIIKEIPYQT NKASLVEKIA ELVENKSLEG ISDIRDESDR SGMRIVIELK RGSEPLIVLN
     NLYRLTALQS SFSCNMVGIL NGQPKQMGLK ELLQAFLDFR CTVVERRARF KLSQAQDRRH
     IVEGIVIGLD NLDGVIRIIR QASSNAHASA EFNLSEKQAE AILDISLRRL TLLERKKFVD
     ESKSLMEQIL KIEQLLSTRE NILQLIEQEA IELKNKFSSP RRSILEETDG GQVEDIDVIP
     NEEMLLALSE KGYLKRMKPN TFNLQNRGTI GKSVGKLRVN DAMSDFIVCH AHDHVLYFSD
     KGIVYSARAY KIPECTRNAA GTPLVQMLSL SDGERITSIV PVKEFPEDQF LLMLTVSGYI
     KKVSLNSFSS IRSTGIIAIQ LVPGDELKWV RLCTNDDLVA MASQNGMVIL SSCDIIRTLG
     RNTRGSVAMR LKEGDKMACM DIIPSSMRKN LEIVSDAPQS KDKGLKGPWL LFVSESGYGK
     RVPLSRFRTS ALNRVGLIGY KFSSEDRLAA VFVVGFSLSE DGESDEQFVL VSQSGTVNRI
     KVRDISIQSR YARGVILMRL EYAGKIQSAS LISGAETDSE EEVAAHG
//