ID A0A218YZ19_9HELO Unreviewed; 2132 AA.
AC A0A218YZ19;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=BcPKS12, polyketide synthase {ECO:0000313|EMBL:OWP00295.1};
GN ORFNames=B2J93_3706 {ECO:0000313|EMBL:OWP00295.1};
OS Marssonina coronariae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Dermateaceae; Marssonina.
OX NCBI_TaxID=503106 {ECO:0000313|EMBL:OWP00295.1, ECO:0000313|Proteomes:UP000242519};
RN [1] {ECO:0000313|EMBL:OWP00295.1, ECO:0000313|Proteomes:UP000242519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NL1 {ECO:0000313|EMBL:OWP00295.1,
RC ECO:0000313|Proteomes:UP000242519};
RA Cheng Q.;
RT "Draft genome sequence of Marssonina coronaria NL1: causal agent of apple
RT blotch.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWP00295.1}.
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DR EMBL; MZNU01000330; OWP00295.1; -; Genomic_DNA.
DR STRING; 503106.A0A218YZ19; -.
DR InParanoid; A0A218YZ19; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000242519; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000242519};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 382..810
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1638..1719
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1764..1841
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1723..1767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1723..1755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2132 AA; 230792 MW; BC91C4C702E4E7C7 CRC64;
MAEKMAFLLF GDQSLGVYEF LADFYQHGNP SVLALSFLDQ VAAALREEVD RMSTVERHRV
PYFSSIKDLN ENYQAKKIKN SAVDSALLCI TQLAHYIDRS EKVPEDVTQP EDTCLVGLCT
GLFAAAAIAS SQSLSTLVPI AVQVTLMAFR AGAHVTAMAE RLHKDTISSE PWTYVLPSIT
EDETRLVLDK FHNDAGIPSV NRVYISAITS NSIAISGAPA SLKLLFDFQS FEAKPIPIPV
HGPYHAAHLH SVFDADKILR TGDSHVQRVL GQAKPRYPVL SCRTGELYSE ENSISLIQHI
LRDILTEPLR FPKVVHGSIL KAQSYRGPKC LVIPFGPTKA ATTLATILKA QTSLDIILRR
SPSTATRPTP TSNNFANGSN GRCKLAIVGM AGRFPDAASH EKLWDLLEKG LDVHREVPKD
RFDAKTHTDT AGKTRNTSHT PYGCWIENPG LFDPRFFNMS PREALQTDPM QRLSLVTAFE
ALEMAGYVPN RTRSTKLDRI GTFYGQTSDD WREINAAQDV DTYFITGGVR AFGPGRINYH
FGFSGPSFSI DTACSSSAAA IQLACTSLWA GDCDTAIVGG VSCMTNSDIF AGLSRGQFLS
KTGPCATFDN DADGYCRADA VGSVIVKRLE DALADKDNVL AVILGTATNH SADAISITHP
HGGTQELLYQ SILARAGVDP LDIDYVEMHG TGDGTEMRSV TNVFAPVDRK RTAEQPLYLG
AVKANVGHGE AASGVTALIK VLMMLQKNAI PPHVGIKNTI NKGFPSDLAE RNVHIAFHKT
PLRKRTNAPR RVFVNNFSAA GGNTGLLLEE APSVNRAAID PRSSHVVTVT AKSKSAMLRN
AQNLISYLTQ HPTISLADVA YTTSARRIQH NWRMSIATTD ISEAAGLLGS KLAADFVPVP
SDPPKVGFLF TGQGSHYAAM GKELYTTSTL FKETIDDFDT IATIHGFPSF VSLIDGGAGD
VQTLSPVAVQ IGIVCLEMAL AKLWDSWGIK PAVVLGHSLG EYAALNVSGV LSASDAIYLV
GSRAQLLVRK CTPGTHVMLA VQGSLESVTK TLGRQAESVN IACVNSIRET VLSGEAAELS
QISDLLTGSG YKCTQLKVPF AFHSAQVDPI LDEFQKTADP INFGKAGVPI ISTVLGRMLD
EHEAVDAVYL RNHARNRVNF AGGLQSAQLA GAINDKTVWI EVGPHPVCSN MAKATLGIST
ITAPSLHRGE SAYKTIAHSL CTMHTAGLNI DWNEYHRDFS DSVHLLDLPT YSFDDKNYWI
QYEGDWCLTK GDGAAGRITP LLEDTKPKLS TTSVQKIVSE SVKDNTAVVR AESDLAEPNL
RGVVTGHLVN GAMLCPSSLY ADMAMTLAEY AYRLVRPDAM DLGMNIANMK VPKPLIARPD
GASQILSVRA TVDVIAGKAD LVFSTGSDKT KVDHGICEVF FSSNKDYLAE WQRTAYLIKS
RIDWLEAAEK SGGAHKVGRG LAYKLFAALV DYNPRYRGMG EVILHSENFE ATAKVDFQTN
DGNFKNSPYW IDSVCHISGF IVNGSDAVDS RENVYISHGW ESLRFAEPLS KDKTYRSYVR
MQPEEGKVLA GDVYIFDGDR IVGMVGCLKF QCLPRKVLNM FLPPVGAKAL GDKSSPVPAN
APASKKSKTA QVTMANIASV NKKLTTMCTR ALEILAAEVG VGMDELVDNI GFSDLGVDSL
MSLTVSGRIR EELEIDVHSH DFNDHPTIGS FKAFLGKFET GIPSSTSSDT HSLSSADKST
SGLVDDSNVT TPLEDSTVED NDDSKDEGLG DLIRVTIAEE MGVDVTEIAE TIDLSSLGMD
SLMSLSILGR LREKTDMSLP ADLLTANQTI REIKTSLGIG APAKPVGPVL VVSKTVASNI
VTPDVNVLQP RRSATSVLLQ GNSRRASKTL WLIPDGGGSA TSYVDIPDLS PDVAVFGLNS
PYMKNPEDYT CGVIGMASAF IVEIKRRQPA GPYTLAGWSA GGVVAFEAVN QLTRAGDVVD
KLILIDSPCP DIIEPLPLSL HRWFASIGLL GDGDISKLPP WLLPHFAASV NALSTYTPES
IEPSRCPRVT AIWCEDGVCK LPSDPRPDPF PYGHAQFLLD NRTDFGPNLW DRYLDPEKFE
CKHMPGNHFS MMKAPHVAEL RDMIIDAINA VV
//
