ID A0A218YZE4_9HELO Unreviewed; 1517 AA.
AC A0A218YZE4;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=B2J93_1326 {ECO:0000313|EMBL:OWP00723.1};
OS Marssonina coronariae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Dermateaceae; Marssonina.
OX NCBI_TaxID=503106 {ECO:0000313|EMBL:OWP00723.1, ECO:0000313|Proteomes:UP000242519};
RN [1] {ECO:0000313|EMBL:OWP00723.1, ECO:0000313|Proteomes:UP000242519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NL1 {ECO:0000313|EMBL:OWP00723.1,
RC ECO:0000313|Proteomes:UP000242519};
RA Cheng Q.;
RT "Draft genome sequence of Marssonina coronaria NL1: causal agent of apple
RT blotch.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWP00723.1}.
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DR EMBL; MZNU01000309; OWP00723.1; -; Genomic_DNA.
DR STRING; 503106.A0A218YZE4; -.
DR InParanoid; A0A218YZE4; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000242519; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000242519};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 3..377
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1021..1188
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1197..1506
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 102..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1517 AA; 166348 MW; B5DD62D6619ED53B CRC64;
MEPGECTSNV IAFNNFASIN YEYFESQTVR AGIAREHLQR TEAGWRQEGR LVHYDPCRDG
IWVFQNATGT GTPTKHNEIS AIDVQGLGLL LKDKGTYEPA SLARGKQASN VLTTPSTSSS
PSSSLESALR NVQAFNARSV QTNSNIGLMQ DPPTPSPGPK PELHNSLKDM HENFISSVLS
STVYFLCHDH GFIPLNSRTL ILPSSDSPQS SLRPGNGIEL ATLDISLTSL GVLVIKAYAD
MAPGLQTSVS ATTSASIAGG LSPGSSLWLA PSGTAAKLHK APDEKNLPSS TSIAQLQEDP
LDSRSNGTNN LTINGWQSRC LEWLSVKGLN STALEAGGWL HVQILGGHNP YYNSDLQATP
ILDESAIVPW PALLCFQTSA PRSQDPQLWG SGPSDCRDPL SFAEEWLTSG DERAATVSKR
QKEREAVEAL SREQADLEAR AQQSNTYSPA ALRRSSNAGA MYPTPPDAPQ PHVGATPSFD
GNASTPGNPN HLIAQDTSSI VPSNRSAADV DNELWGSSGK KERRISGNQY SYNDKDSDHE
NDNGNEHLFG DIGGDMFGTH ITDDDFNFFD EPDVDDFDQK VPSPLPENQP GIQEGTIMSN
NPSSSDIMLQ ALETHDLELA STDHGDPSRQ INNLKISHPI DITAQIPTFQ QKDVKVEAVQ
LPQPHISLPF NKEAIFQRLD QEQRGHKIHK QFRRASLFGQ IVFEESLQSV NKKYSSHGQF
SFCSKKKPRK LEIVSGLPQT DYLTSRRKSR DNILEMRHVA RILGEKKLDS EPNLRDPIDY
LLGSDEGSPV SEQDDSSHAT EEPLISPQSG MKRKWESDDQ DDIASTFDGL AVDFELCAST
PQSTSGSQMP LLDADPAGWA LTTYFTSPEP AVDAEPNILT DLECIATAQI LADQAISGTL
RLPDTASNET YMLPDTTSAT RRLMYSLSQA LKSCLTDGNT CTMRSFLDIQ GIPVLNQALR
LPPRPMQNPR GPIGQDARPN NPFPIPPPQL EVRRSETRMS ILPASVPFWE NLGLGPSRGT
KDVNAVCVYP NLDGLARYAS TFLDQMKSVY ESSRFGAHDR LASKEIDNGL LPFAIDILPQ
NKMQNLTVLR EIVSRLSRNL ASLTAGEKNH VVYFVYPVDN KVLLVHICSA FQHLFNLYRK
ALSERRTSPT NELVLQLIPM DFIASPTSLA VPLPLKYFHL SMEVYDRCID FSSSTSSPAI
MLEQPLPRTI DFKLSLNPSA SLLQENTCLH IAYAQSIDDR WITAAWTDNR GTRQMTASYC
LGRKNEPIST PFMDVANEIW ETTLQVISSK NIHWRIIIAR VGVMDNTELD FWTGLASTES
NAQISLTLVT VQTNPSLRLL PAPVTLTPNG STAQTVFTPV STPQALQSSI GSPDTVTTLT
RGVPSSSTPV EALVEPDSDA RLVDHTDQSW GAVLSHRLNN SNSLVETNPA LISGYLLKRG
GFNNNDPPVI MEVNIVHSEV VGNPRTFHES ILREILGYYR GLGTLARTRG VVDAVKDIRP
WHIAAAEKAV KALYMLM
//
