ID   A0A218Z8D7_9HELO        Unreviewed;      1243 AA.
AC   A0A218Z8D7;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   28-JUN-2023, entry version 20.
DE   SubName: Full=Nonsense-mediated mRNA decay factor (Upf2) {ECO:0000313|EMBL:OWP03436.1};
GN   ORFNames=B2J93_7454 {ECO:0000313|EMBL:OWP03436.1};
OS   Marssonina coronariae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Dermateaceae; Marssonina.
OX   NCBI_TaxID=503106 {ECO:0000313|EMBL:OWP03436.1, ECO:0000313|Proteomes:UP000242519};
RN   [1] {ECO:0000313|EMBL:OWP03436.1, ECO:0000313|Proteomes:UP000242519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NL1 {ECO:0000313|EMBL:OWP03436.1,
RC   ECO:0000313|Proteomes:UP000242519};
RA   Cheng Q.;
RT   "Draft genome sequence of Marssonina coronaria NL1: causal agent of apple
RT   blotch.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWP03436.1}.
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DR   EMBL; MZNU01000176; OWP03436.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A218Z8D7; -.
DR   STRING; 503106.A0A218Z8D7; -.
DR   InParanoid; A0A218Z8D7; -.
DR   OrthoDB; 276824at2759; -.
DR   Proteomes; UP000242519; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   Gene3D; 1.25.40.180; -; 3.
DR   Gene3D; 4.10.80.160; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   InterPro; IPR039762; Nmd2/UPF2.
DR   InterPro; IPR007193; Upf2/Nmd2_C.
DR   PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR   PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR   Pfam; PF02854; MIF4G; 2.
DR   Pfam; PF04050; Upf2; 1.
DR   SMART; SM00543; MIF4G; 2.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242519}.
FT   DOMAIN          462..652
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   DOMAIN          667..874
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   REGION          154..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          908..983
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          996..1049
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1104..1159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1175..1219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        908..923
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        929..950
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        996..1023
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1024..1049
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1140..1156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1182..1213
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1243 AA;  139397 MW;  D24554B358EC9E2D CRC64;
     MDRRRKRELR ELNSRAWNGE KDIFALNKSL DSSLKKNTAF IKRLRTAVSA AALGTFLQEI
     RTLSLHKYLS EIVSACYEGL CKLKSPGEIE AGVEIVSALH QRFGPAEFTK FLGWLVAAEA
     REKEEKERII RQRVLLRVVT ELWLVGVIRT LDDVSRPDDS SRGKESLSGN AGKSSDVKGK
     PGLASKGGGA EPFPLEVLKD LLGHDREHAN LPLLVIFVKA FGWDILGVKE PGSEGRKTVE
     ADGATTEANV VGDAHDKSAS ASPLGTAIED PPLASAELQE RFRNILKRYF EDVKTHLLRD
     QKAISKQARK DAEAYVKSGQ VFEDRQANYE KAVKAQERLI ANAQVLADAV GGEMPDLKES
     DDNSGAGNGG IGLVKTGEYL RGEADGAGIW EDEDERRFYE NLVDLKGKVP GMLLEDGRKK
     KADTDEQVGK RVIQADAISE PTSTKEDDMS TAIANKTIGT QVDALLARLP DLTNKDLIDQ
     AAVDFCFLNS KASRNRLVKA VQEIPKGRSD LLPSYSRLVA TLGKYMPDIT KSLVDHLDQE
     FRSLQRRKEK EFLGQARLGN IRYLAELTKF GVVPEHVIFH CLKVSLDDFS RMNIEIICNL
     LENCGRYLLR NPETSPRMTS FLETLKRKKS VQHIGQQERM LVENAVYYVD PPVRAAIQQK
     ERTPIDLFIR KLIYLDMNTR NYTKILRQIR RLHWEETEVV AILEKVFSKP GKVKYGSIHL
     LAIMLISLYR YHQQFVIMVI DNVLESVVLG LEQNDFKFNQ RRMAELRYLG ELYNYRMVDH
     SVIFDTLYRI LTFGHGGPPI PGRSNPFDMP DDFFRIRLVA TVLESCGMFF NRGAAGKKLD
     YFLSFFQYYI YTKDQLPMDI EFIVQDVFAL TRPQWKLASN IEEASRAFQL AIAQDQKTSG
     MDKVLEAEAD DGESDKSSDD GLGDMEAEGG LPEADDEGDF ESEDEIDIDA NGDTVPSAPD
     TDSEEESIVV TRQEEEIDPE DEADFDRELA KLMAESLDSR KHERKPTFDV PLPMRRKEQT
     PHHVTATNES WTEDSPKDNS PSGIPTGTMA FSLLTKRGNR QQTRTVALPS DSTFAVAMKT
     KQAAEREEQK RIKDLVLNYD LRDGEEQDGD STLAPLNPNF NIHGSKAGLD KAAGTNAARP
     ADRSGNTRSA QRNRKLQLSD VDWYESKKNL LYVENKPVKD SKENAQSSGP SIKKPVMNST
     PVGNPSGERA MQTARVSRQV GGRLIRKAIL EAYASDTKKR GTK
//