ID A0A218Z8S6_9HELO Unreviewed; 2565 AA.
AC A0A218Z8S6;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=B2J93_3415 {ECO:0000313|EMBL:OWP04467.1};
OS Marssonina coronariae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Dermateaceae; Marssonina.
OX NCBI_TaxID=503106 {ECO:0000313|EMBL:OWP04467.1, ECO:0000313|Proteomes:UP000242519};
RN [1] {ECO:0000313|EMBL:OWP04467.1, ECO:0000313|Proteomes:UP000242519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NL1 {ECO:0000313|EMBL:OWP04467.1,
RC ECO:0000313|Proteomes:UP000242519};
RA Cheng Q.;
RT "Draft genome sequence of Marssonina coronaria NL1: causal agent of apple
RT blotch.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWP04467.1}.
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DR EMBL; MZNU01000105; OWP04467.1; -; Genomic_DNA.
DR STRING; 503106.A0A218Z8S6; -.
DR InParanoid; A0A218Z8S6; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000242519; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000242519}.
FT DOMAIN 1253..1380
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 108..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2565 AA; 285538 MW; BE2D29F9EE683118 CRC64;
MNGDSGLVVT LVDRLTTRLP HRTGSSLHDF NRDEIVVLTR GTLVGISSSC IGVVVDALVQ
LLEELSRPFK GIQAHPPHVL HSELYVLDLL SECCSVHWAS LNNSNSLAGG NEQDSDSESS
DSVHEKKLSL PSDASHRQKR CASRDMLVAR SNPPGPLTDD LVKRLIDAVK LFSKPIPENH
VLPATHILDD VFRGLASGDL YSSENPSPGN GLNGSEASKI LLDISEAVEE YTRTIMEYIS
CSNWPRVLDY LRSALQQAAR QPAASPAQAN LAVDDDKSAL VSIRLISSFW VDSRKLSIVV
QELCGSFLHL RKSFQTTVAI VLPLLIARWL ERNPEEFIEL HSTLKKLDGG AETLFDMSNT
IFDGSRRKGL LYPLQTSLLL LLPDVFEYAS NLREAKSSSS ISKKVAFLEM LRKSLRNRNE
TAIYCLTSLL RVARHFPLDS DAAILSYALD VQEEVREAVF RRQSPGMDSA NIDSSLMSAA
FVSLAHLNFE SCMENLAPIC LAPNAPLDFQ TSVISACSYF ARQANADEYQ PLFTRIADFI
RAQLRLSASR QRESYPDDQY NLLKPLDVSE SADLIYSILS FLEASSLTLF NGAPKFGLEW
ISFYEEIFTS FTVYLAAEDE RIRSLANTVA RKIMMEGTVT FWRKSQSLGL KTFKYNFWKT
TSYILMIAAE KLLNIGTDEK GTLRFVHDFL ESRIALLGTI EDLIEAAGDM PERLATCTKL
ETALLINLCS TNISVCQLVT KCISLFCEEA RLVDGISGAN KSLPPTLRNI EIYSQISARD
FRFTGLVAFQ KRVRGLLRQT KHPTAGILTA WEMVFDYWLE SSKHIFSRSS NLLEERSLVE
WRNHSGFLAS LGGACISGQA LAAEDTGLAG LRWIDRGFPE SYDESLLHKF LKQSIRLLAS
SNVRIREATR ETLSTELSPS LYLPLFEVLE SELGVLFDTT RTNTSLSLES RVIFVEQAAA
LLRSIVDQLG GSAEAGIALS IDVGALTLNF AKFLDDLAEG ASILRVKIKI CQLCETVSQK
KELLNLRHDV RIRNQLLEVI FSWIARPGSP KDAVITSGAR IEELPRLQRD VDRACLKALA
DLTYRLPLQP AEGQTDADTS DLKSQMFHTY FNRFLSLLNF EAAEAGRNEA RLITAVNDDP
LSTSELAITA LSNLLSANID VGLKHSLGIG YHEDLDIRTA FVKVLCNILI QGAEFNNLSD
SAVNEKYDEL LELLINDMNL TIALCDACPS MEVDEMTISL LNIFDSRGLG FLLLEALIEH
EVEGTDLDLE LDPARTASAE ELQKNALQLR VVAKVFIDDI CNSAAHIPIS FRKICSIISS
AVMKKFPEAK FTAVGAFIFL RFFCPAIVAP DVEGLIATAP SKEMRRGLLL IAKVVQNLAN
NVLFGAKEPY MFPLNDFLTQ NIYRVTTFLR EISVPPNVLE PVVESESFDF GSCVALHRFL
YDHWDHVRQK IVVRERKGAM RSLLESSKGQ ISILEALRKL ITNLGPPPMD VSWNRPVISS
NNPHSYSRFQ HFMLRNAGRN TESLVSTRAV YDGGESKDGL PMICIILRNI DTETTDYELL
LFGYLKIASR MWHRPFGILI DATCYNGQNE PQDALFRKLD LLTPSELSKQ LTRVYVYNMN
SPFRKCFRRI LRLAAKSENS AFHPKNVDYH LIGSLQDLQA HFHLSQLHLP KETISVVTDT
RYVFQPIVRL SKTKGKIEVV IKVGSQFVQV TTTKKQEVVP GLRLHATVND IFRLSEVDEA
PTSIQTEDDS AFGLRTENGK IVMYFTSPRK PDVIQAIRGA KAKYGKELRA LKSFERLVRP
QDVPGTLLNI ALSNMANSDQ VLRLASYNLL CALCRAFKFA ADSKFMSAKE LCVPLNPSKF
IIDISQQLAH SEPQLTADFL NEFFVGWESF PYSQRPISLS YMAPWIPGLR TSLVPNDVDS
DKAREKVAII FRRLIEVAIS DVALGTTLEQ NIWPTITADE IYTDIFLDEV VKAALSSGMN
DERTEILGSI IASLGTVTVR GKLLARLRRA LNRTSLRPTR HLPENTVWGE ICVLIRLCLS
TSFDSGVQSQ LFLPEIFHLV TMLANTGPID VRLLVHRLLV NTIHAICTGF GLEESKLARL
KTLLLALSEP RSDPARDGVS VVSFHDSGIP SLIATESLAA LLAEVSTIAA LTVEMSNAWR
SRWMSLVAST AFQSNLAIQP RAFTVMGCLA REDVDDDLLY QVLVTLRSSI GRFMEENDSE
MLIAIVTSLT KMMDKLPSAS RYGMQLFWLA LSLVRLVPLP LFNCTALFLD AVLSNIASSG
EFSRGRMVPT LLQGRIPLED AAQQLDEIYG IHFNIENFHF ALCASLTKGL TDSVTKATAI
RVLSTFLEIT TSNSAHEARF PNDLSAFPYL GLLTARAVTP EESKDNLWLA GWAASDDEVT
AEGVLDMIDL KMVKDKELLL NAAIGIVDFH YLEDTVQNRG LLWLNRISMK RPTVILHLFG
PVVRILDDIL ISCQNAATLE SAHLLMRTIT SNPKFAGGVD TSETLEDVLD GIGFGGLWRS
STFHAVNDHE RECTALTDRL IEASSRSYKL APRIIPLTRI QLIIA
//
