UniProt: A0A218ZEX2

Database: UniProt
Entry: A0A218ZEX2_9HELO

LinkDB:  A0A218ZEX2_9HELO 
Original site:  A0A218ZEX2_9HELO

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Ontology (2)   
   GO (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (6)   
   InterPro (3)   
   Pfam (1)   
   PROSITE (2)   
All databases (10)   

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ID   A0A218ZEX2_9HELO        Unreviewed;       365 AA.
AC   A0A218ZEX2;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   13-SEP-2023, entry version 19.
DE   RecName: Full=Uroporphyrinogen decarboxylase {ECO:0000256|ARBA:ARBA00012288, ECO:0000256|RuleBase:RU000554};
DE            EC=4.1.1.37 {ECO:0000256|ARBA:ARBA00012288, ECO:0000256|RuleBase:RU000554};
GN   ORFNames=B2J93_943 {ECO:0000313|EMBL:OWP05825.1};
OS   Marssonina coronariae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Dermateaceae; Marssonina.
OX   NCBI_TaxID=503106 {ECO:0000313|EMBL:OWP05825.1, ECO:0000313|Proteomes:UP000242519};
RN   [1] {ECO:0000313|EMBL:OWP05825.1, ECO:0000313|Proteomes:UP000242519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NL1 {ECO:0000313|EMBL:OWP05825.1,
RC   ECO:0000313|Proteomes:UP000242519};
RA   Cheng Q.;
RT   "Draft genome sequence of Marssonina coronaria NL1: causal agent of apple
RT   blotch.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen
CC         III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57308, ChEBI:CHEBI:57309; EC=4.1.1.37;
CC         Evidence={ECO:0000256|RuleBase:RU000554};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC       {ECO:0000256|ARBA:ARBA00004804, ECO:0000256|RuleBase:RU000554}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC       {ECO:0000256|ARBA:ARBA00009935, ECO:0000256|RuleBase:RU004169}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWP05825.1}.
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DR   EMBL; MZNU01000060; OWP05825.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A218ZEX2; -.
DR   STRING; 503106.A0A218ZEX2; -.
DR   InParanoid; A0A218ZEX2; -.
DR   OrthoDB; 34606at2759; -.
DR   UniPathway; UPA00251; UER00321.
DR   Proteomes; UP000242519; Unassembled WGS sequence.
DR   GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00717; URO-D; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   HAMAP; MF_00218; URO_D; 1.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR   InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR   NCBIfam; TIGR01464; hemE; 1.
DR   PANTHER; PTHR21091; METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED; 1.
DR   PANTHER; PTHR21091:SF169; UROPORPHYRINOGEN DECARBOXYLASE; 1.
DR   Pfam; PF01208; URO-D; 1.
DR   SUPFAM; SSF51726; UROD/MetE-like; 1.
DR   PROSITE; PS00906; UROD_1; 1.
DR   PROSITE; PS00907; UROD_2; 1.
PE   3: Inferred from homology;
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793,
KW   ECO:0000256|RuleBase:RU000554};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000554};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU000554};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242519}.
FT   DOMAIN          26..35
FT                   /note="Uroporphyrinogen decarboxylase (URO-D)"
FT                   /evidence="ECO:0000259|PROSITE:PS00906"
FT   DOMAIN          151..167
FT                   /note="Uroporphyrinogen decarboxylase (URO-D)"
FT                   /evidence="ECO:0000259|PROSITE:PS00907"
SQ   SEQUENCE   365 AA;  40806 MW;  11AEDAFB39A99E03 CRC64;
     MAHEFEPLKN DLILRTAWGQ KVERPPMWVM RQAGRYLPEY HEAKGTNDFF ACCRSPEIAS
     TLTLQPIDRF AGLIDAAIIF SDILVVPQAL GMAVEMVDKK GPHFPEPLKS PDDGQYGKVL
     SKNVDVAAEL DYVYKAITLT RHKLKGRVPL FGFCGAPWTL LCYMVEGGGS KLFIQTKTWI
     YRYPQATKDL LQKIAEICVE YLALQVQAGA QLIQVFDSWA AELSPDAFKE FSQPYLAYIS
     ANLPKRLREL KLDPVPMVVF AKGAWYALDS LCDLGYQVVG LDWLQDPAEA VRTRGDRPVV
     FQGNADPGIL YGTRENITST VEKIVRGFGG GKQGWIANLG HGITPGVNPD DLKFYFEELH
     RITST
//

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