ID A0A219AJM3_9EURY Unreviewed; 470 AA.
AC A0A219AJM3;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Lactaldehyde dehydrogenase {ECO:0000256|ARBA:ARBA00019663};
DE EC=1.2.1.22 {ECO:0000256|ARBA:ARBA00013052};
GN ORFNames=BGI41_05720 {ECO:0000313|EMBL:OWT32807.1};
OS Methanobrevibacter sp. 87.7.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=387957 {ECO:0000313|EMBL:OWT32807.1, ECO:0000313|Proteomes:UP000197485};
RN [1] {ECO:0000313|EMBL:OWT32807.1, ECO:0000313|Proteomes:UP000197485}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=87.7 {ECO:0000313|EMBL:OWT32807.1,
RC ECO:0000313|Proteomes:UP000197485};
RA Yeoman C., Mosoni P., White B.;
RT "De novo assembly of methanobrevibacter sp 87.7.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:14277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16651, ChEBI:CHEBI:18041, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.22;
CC Evidence={ECO:0000256|ARBA:ARBA00001091};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005036}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWT32807.1}.
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DR EMBL; MRCT01000100; OWT32807.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A219AJM3; -.
DR OrthoDB; 6342at2157; -.
DR UniPathway; UPA00071; -.
DR Proteomes; UP000197485; Unassembled WGS sequence.
DR GO; GO:0008911; F:lactaldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR NCBIfam; NF040648; lactal_redase_Meth; 1.
DR PANTHER; PTHR42991; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42991:SF1; ALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345}.
FT DOMAIN 12..464
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 244
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 470 AA; 50658 MW; E8EEB22717BED7AC CRC64;
MDILINGKHV SKDETMDVIN PYDNSIIDTI PIADKNDVND VIIAANNAKS KIMEFSSRKV
SNLLFDAYDD LKENSKKLAK VITEETGKPI KGSIGEMDRS VETLRFAAEE AKRIYGESVP
LDAGLGGKGF YAFTQKIPLG VVAAITPFNY PVNLAIHKLG PAVAAKNTVI LKPSREAPLS
GLMLAEIMAN HFPDGVINSI TGLGEEIGDA LVTAENVDKI SFTGSVPTGL SIANNSGMKK
LTLELGGNDP VIVLDDANID KAVKGVVNGA YLFSGQVCMG VKRVIVDVKV IDEFIDKLVK
ATKKLKVGNP MDENTDIGPL INNKAVKMVE QSVNNSIENG ANLEIGAKIK DNFYWPTVLT
DVKPEMDLVK NETFGPIAPI IGVNGVDEAI SVANNTRYGL QAGVYTENIR NALKCTQEIE
AGSVFVNKQS TFRTDNMPFG GFKLSGVGKE GVKYAVEDMC RTKLIGFNLR
//
