ID A0A219AKR3_9EURY Unreviewed; 609 AA.
AC A0A219AKR3;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=BGI41_04235 {ECO:0000313|EMBL:OWT33090.1};
OS Methanobrevibacter sp. 87.7.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=387957 {ECO:0000313|EMBL:OWT33090.1, ECO:0000313|Proteomes:UP000197485};
RN [1] {ECO:0000313|EMBL:OWT33090.1, ECO:0000313|Proteomes:UP000197485}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=87.7 {ECO:0000313|EMBL:OWT33090.1,
RC ECO:0000313|Proteomes:UP000197485};
RA Yeoman C., Mosoni P., White B.;
RT "De novo assembly of methanobrevibacter sp 87.7.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWT33090.1}.
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DR EMBL; MRCT01000061; OWT33090.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A219AKR3; -.
DR OrthoDB; 323192at2157; -.
DR Proteomes; UP000197485; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 65..319
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 395..596
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 414..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 71338 MW; 350ABAEF607C1A22 CRC64;
MEREMIVLDI DYITEGEKPV IRLFGREPGE NPKRIIAFDN SFEPYFYIEA ENINQCLKDL
EKYDTKNIEI VDKKDFQIPK KFIKITFTHP QEVPKYRDEI RELDSVIDIR EHDIPFYRRY
LIDNNIVPMS LVSVKGDLIE SHESIDNNYD NLEILNLSEV PKSLNDTVSD FRIIAFDLEV
YNPRGLPNSN VDEIIMIGLN SNFGIKKVLS TKTKVDADDS FIEKFDSEKQ MIEEFIRIIK
DNQVDIIVGY NSDNFDFPYL NDRAKLYGID LDLSMDGSSI KFIKRGFTDA ASFKGLLHID
LYFVMRRYMT LDRYTLERVY YELFGEEKKD VPGEIIWKYW DSNNEYLNEL FDYSLDDVVS
TLMIAQQTLP LNLELTRIVG QPFFDITRMT TGQQAEWYLV KRAYDIDEII PNKPSAGDKS
RTHDKNEGGF VKEPEPGLHE NLVQFDFRSL YPSIIISKNI CPDVLVTDKG NPLDTTDDAF
PDEERYYVCP QHKHKFLKKP KGFIPSVIGD ILRERLRIKK QMKTSSNPTE KKVLNIQQLA
IKRLINTMYG VYGYSRFRWY SFECAQAITA WGREYILYTI ESAKKYGFYA IYADTDGFYA
EYRKDVNSN
//
