ID A0A220S0B2_9NEIS Unreviewed; 727 AA.
AC A0A220S0B2;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Polysaccharide biosynthesis tyrosine autokinase {ECO:0000313|EMBL:ROV56841.1};
DE EC=2.7.10.2 {ECO:0000313|EMBL:ROV56841.1};
DE SubName: Full=Tyrosine protein kinase {ECO:0000313|EMBL:ASK26863.1};
GN ORFNames=BG910_03090 {ECO:0000313|EMBL:ASK26863.1}, EGS38_03105
GN {ECO:0000313|EMBL:ROV56841.1};
OS Neisseria chenwenguii.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=1853278 {ECO:0000313|EMBL:ASK26863.1, ECO:0000313|Proteomes:UP000198238};
RN [1] {ECO:0000313|EMBL:ASK26863.1, ECO:0000313|Proteomes:UP000198238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10023 {ECO:0000313|EMBL:ASK26863.1,
RC ECO:0000313|Proteomes:UP000198238};
RA Zhang G.;
RT "Neisseria chenwenguii sp. nov., isolated from the intestinal contents of
RT Tibetan Plateau Pika in Yushu, Qinghai Province, China.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ROV56841.1, ECO:0000313|Proteomes:UP000270353}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10010 {ECO:0000313|EMBL:ROV56841.1,
RC ECO:0000313|Proteomes:UP000270353};
RA Zhang G.;
RT "Neisseria chenwenguii sp. nov. isolated from the rectal contents of
RT plateau pika (Ochotona cruzoniae).";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; CP022278; ASK26863.1; -; Genomic_DNA.
DR EMBL; RKIL01000003; ROV56841.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A220S0B2; -.
DR KEGG; nei:BG910_03090; -.
DR OrthoDB; 9808257at2; -.
DR Proteomes; UP000198238; Chromosome.
DR Proteomes; UP000270353; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ASK26863.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000198238};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ROV56841.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 30..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..104
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 365..445
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 537..651
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 267..294
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 339..369
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 727 AA; 80176 MW; E4F9D659BF1454E9 CRC64;
MNNKYSASAA YAKDEIDLGR QLSGLWAHKY KIALAVLIGG ALGAVYSLAA TPVYRADAML
EIETKQNQIL TEISNIFSTE PLPSEAELEL VQSRMVLGKT VADLQLDQEV KPKYFPVFGT
LMHNLTSNIE PKLDITAFTV QRDWINQAFT LTVRDSKSYI LELPDGRSLE GRVGKPLKVN
NETVLLIDKI LADSQQEFSL VKFSQLSAID NVHNKLSVIS NGKTNPIIEL NYTDTDPKKA
SLILNSIADN YVEQNRARDI QVASSGLAFI SEELPRLKET LQEAENKLNA YRERSGSLDI
PLESKGAIES LTGIETQITT LRTEEAGLAE RYTPEHPSYK AVLDKLAVLE NAKNKINRQI
AELPNTQQEV IRLTRDVETN QATYVQLLNK QQELNIMKAS AQGNVRVVDH AIEPEIPVAP
RKAVITLLAA LGAGALTSLW YLLRTRIRSG ITSSEDIENI GFEVAALVPY SKTQQKRDVL
KNRFKSITGR NSYLLASDES TDLAVEALRA LRTNIYFSMM DARNNILMVT GAAPEAGKSF
VSANLAAVMA QAGKKVLLID TDMRKGYLDK VFGVKAEYGL ADVLTGNAAP GYAVQATQIE
NLSLITNGGY PENPSELLMD NRFSDLLAYA RERFDYVIID TPPVLAVTDA AIIGQHAATT
LMVARYGLTT SRELTISADR LKQSNINVKG VILNGMEREA GSGYDYYAYE SRSNKDYTKK
SSTDKQA
//
