ID A0A220S1M9_9NEIS Unreviewed; 315 AA.
AC A0A220S1M9;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:ASK27313.1, ECO:0000313|EMBL:ROV57011.1};
GN ORFNames=BG910_05800 {ECO:0000313|EMBL:ASK27313.1}, EGS38_02360
GN {ECO:0000313|EMBL:ROV57011.1};
OS Neisseria chenwenguii.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=1853278 {ECO:0000313|EMBL:ASK27313.1, ECO:0000313|Proteomes:UP000198238};
RN [1] {ECO:0000313|EMBL:ASK27313.1, ECO:0000313|Proteomes:UP000198238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10023 {ECO:0000313|EMBL:ASK27313.1,
RC ECO:0000313|Proteomes:UP000198238};
RA Zhang G.;
RT "Neisseria chenwenguii sp. nov., isolated from the intestinal contents of
RT Tibetan Plateau Pika in Yushu, Qinghai Province, China.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ROV57011.1, ECO:0000313|Proteomes:UP000270353}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10010 {ECO:0000313|EMBL:ROV57011.1,
RC ECO:0000313|Proteomes:UP000270353};
RA Zhang G.;
RT "Neisseria chenwenguii sp. nov. isolated from the rectal contents of
RT plateau pika (Ochotona cruzoniae).";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP022278; ASK27313.1; -; Genomic_DNA.
DR EMBL; RKIL01000002; ROV57011.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A220S1M9; -.
DR KEGG; nei:BG910_05800; -.
DR OrthoDB; 9805416at2; -.
DR Proteomes; UP000198238; Chromosome.
DR Proteomes; UP000270353; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12162; 2-Hacid_dh_4; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000198238}.
FT DOMAIN 27..314
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 106..285
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 315 AA; 33899 MW; 7B6E530E68504B21 CRC64;
MTLKIVVLDR DTLPGHKFAF DFPHGLTCYG TSRPEEASER IRGADIVITN KAVVSAEAVA
ENPQLKLIAV AATGVNNVAV EAAKKAGVAV CNVRSYGNES VAEHAFMLMI ALMRNLPAYQ
RDVAAGAWQK SPFFCHYGAP MRDLNGKTLA IFGRGNIGRT LAGYARAFHM NVIFGEHKHA
ETVRDGYVSF DKAVQTADVI SLHCPLTEQT ADMIGAAEFA RMKPEAILIN CGRGGLVNEP
ALITALQNGT IGGAGFDVLT QEPPVNGNPL LSYGLPNLIV TPHTAWASRE AFDNLFNILL
DNVNRFIAGK PQNLV
//
