ID A0A220S386_9NEIS Unreviewed; 762 AA.
AC A0A220S386;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=CRISPR-associated helicase/endonuclease Cas3 {ECO:0000313|EMBL:ASK27934.1};
GN ORFNames=BG910_09505 {ECO:0000313|EMBL:ASK27934.1};
OS Neisseria chenwenguii.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=1853278 {ECO:0000313|EMBL:ASK27934.1, ECO:0000313|Proteomes:UP000198238};
RN [1] {ECO:0000313|EMBL:ASK27934.1, ECO:0000313|Proteomes:UP000198238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10023 {ECO:0000313|EMBL:ASK27934.1,
RC ECO:0000313|Proteomes:UP000198238};
RA Zhang G.;
RT "Neisseria chenwenguii sp. nov., isolated from the intestinal contents of
RT Tibetan Plateau Pika in Yushu, Qinghai Province, China.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; CP022278; ASK27934.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A220S386; -.
DR KEGG; nei:BG910_09505; -.
DR Proteomes; UP000198238; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR PANTHER; PTHR47962:SF5; ATP-DEPENDENT HELICASE LHR-RELATED; 1.
DR PANTHER; PTHR47962; ATP-DEPENDENT HELICASE LHR-RELATED-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Endonuclease {ECO:0000313|EMBL:ASK27934.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000198238}.
FT DOMAIN 17..184
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 253..440
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 762 AA; 84984 MW; 5B64E4F73E93B77B CRC64;
MQEQFQPYYA HSAENRPESE WQTLSSHLTA VGQAAAEFSA FFGAQEIARY TGLLHDLGKY
SARFQQRLRG GKPVNHSTAG AKIAVKTWGN LGNMMAFCIA GHHAGLADGA GSGNGRTVLN
DRLKEAFGAD IPELDPIWQA EIGGLPEKLA ATPPVLPKIK ELQAFSRAFY TRMLYSCLVD
ADFLDTEKFY LGLENQTPAR GSYPSLEQLQ QRFQAFLDAF RQKTAQNRVD TPELQRNAGL
NRLRSEILDH AVAQAGLPPG LFTLTVPTGG GKTFTSMAFA LKHALAHDLR RVIYVIPFTS
IIEQNAAEFR KAFGDLGEAA VLEHHSTFND ETIQDRNSRD KLHRASENWD MPIVVTTAVQ
FFESLFADRS SRCRKLHNIT GSVIILDEVQ MLPPKLLQPI LAAIDELARN YRCTVVLCTA
TQPALHKVHY FQETFAGLRE LAPNPPELFK QLQRATVRHI GLQNDDALQE KLAEHPQILI
IVNNRRHARS LYDQVKTVHS DGLFHLTTLM CAAHRQNILA EIKGRLKNGQ PCRVIATSLI
EAGVDVDFPV VMRAESGLDS VAQAAGRCNR EGKNLPENSP VYVFQTAEEW KTPPELAVQA
AAMRSVFRND AHRDLLSPPA ITQYFKELYC AKGTALDDKQ ILHTIHANGP NFPFQTVAEK
FRMIENHMQP VIVPFDAKAE ELIDALRHAD HIGGLLRKLQ PYTVQIPEKA LDALYAAGRI
EALNEAKFGR QFWCLIGLDL YDETAGLSWE DADFLKAESM II
//
