ID A0A220TYS5_9BACI Unreviewed; 305 AA.
AC A0A220TYS5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA-3-methyladenine glycosylase II {ECO:0000256|ARBA:ARBA00012000};
DE EC=3.2.2.21 {ECO:0000256|ARBA:ARBA00012000};
GN ORFNames=CFK37_01395 {ECO:0000313|EMBL:ASK60957.1};
OS Virgibacillus phasianinus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Virgibacillus.
OX NCBI_TaxID=2017483 {ECO:0000313|EMBL:ASK60957.1, ECO:0000313|Proteomes:UP000198312};
RN [1] {ECO:0000313|EMBL:ASK60957.1, ECO:0000313|Proteomes:UP000198312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LM2416 {ECO:0000313|EMBL:ASK60957.1,
RC ECO:0000313|Proteomes:UP000198312};
RA Tak E.J., Bae J.-W.;
RT "Virgibacillus sp. LM2416.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-
CC methylguanine, 7-methylguanine and 7-methyladenine.; EC=3.2.2.21;
CC Evidence={ECO:0000256|ARBA:ARBA00000086};
CC -!- SIMILARITY: Belongs to the alkylbase DNA glycosidase AlkA family.
CC {ECO:0000256|ARBA:ARBA00010817}.
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DR EMBL; CP022315; ASK60957.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A220TYS5; -.
DR KEGG; vil:CFK37_01395; -.
DR OrthoDB; 9785929at2; -.
DR Proteomes; UP000198312; Chromosome.
DR GO; GO:0003905; F:alkylbase DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0008534; F:oxidized purine nucleobase lesion DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd00056; ENDO3c; 1.
DR Gene3D; 3.30.310.20; DNA-3-methyladenine glycosylase AlkA, N-terminal domain; 1.
DR Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR InterPro; IPR037046; AlkA_N_sf.
DR InterPro; IPR000035; Alkylbase_DNA_glycsylse_CS.
DR InterPro; IPR011257; DNA_glycosylase.
DR InterPro; IPR003265; HhH-GPD_domain.
DR InterPro; IPR023170; HhH_base_excis_C.
DR InterPro; IPR012904; OGG_N.
DR PANTHER; PTHR43003; DNA-3-METHYLADENINE GLYCOSYLASE; 1.
DR PANTHER; PTHR43003:SF12; DNA-3-METHYLADENINE GLYCOSYLASE; 1.
DR Pfam; PF00730; HhH-GPD; 1.
DR Pfam; PF07934; OGG_N; 1.
DR SMART; SM00478; ENDO3c; 1.
DR SUPFAM; SSF48150; DNA-glycosylase; 1.
DR PROSITE; PS00516; ALKYLBASE_DNA_GLYCOS; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000198312}.
FT DOMAIN 140..305
FT /note="HhH-GPD"
FT /evidence="ECO:0000259|SMART:SM00478"
SQ SEQUENCE 305 AA; 35733 MW; AABA25391F028436 CRC64;
MKDFEDHIGF IRIFAPKEFS FSENLKYLSR STNECLFTIA DNKIYRALPI EDVTPLVEIS
GETETIIHVR FFGNTTPDQK AVREKVAEYI QEWFDLKTNL LPFYELAETD PLLHQPVDNF
YGLRVIGIPD LFEALAWGIL GQQINLTYAY TLKRRLVEYF GRYKEWDGVR YWIFPEPGVI
AKLSVEDLSN MRMTVKKSEY LIDVANLITN KELSKEKLMK IRDFKKAEKI LVKIRGIGPW
TANYVLMRCL HYPSAFPIDD VGLHNAIKLI LDLEKKPSKK EILKLSSAWT GWESYGTFYL
WRMLY
//
