ID A0A220U3R7_9BACI Unreviewed; 799 AA.
AC A0A220U3R7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ASK62808.1};
GN ORFNames=CFK37_11945 {ECO:0000313|EMBL:ASK62808.1};
OS Virgibacillus phasianinus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Virgibacillus.
OX NCBI_TaxID=2017483 {ECO:0000313|EMBL:ASK62808.1, ECO:0000313|Proteomes:UP000198312};
RN [1] {ECO:0000313|EMBL:ASK62808.1, ECO:0000313|Proteomes:UP000198312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LM2416 {ECO:0000313|EMBL:ASK62808.1,
RC ECO:0000313|Proteomes:UP000198312};
RA Tak E.J., Bae J.-W.;
RT "Virgibacillus sp. LM2416.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP022315; ASK62808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A220U3R7; -.
DR KEGG; vil:CFK37_11945; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000198312; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000198312}.
FT DOMAIN 8..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..305
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 799 AA; 87870 MW; 7043648C7B631205 CRC64;
MKQTIKRAAV LGSGVMGSGI AAHLANVGIP TLMLDIVPRE RTKAEEKKGL TMEDTAVRNR
MAAESKKALL KQKPSPITSK KSLDLIEVGN MDDDMDKLSE VDWIIEVVVE NLAVKKKVFA
NVDKYRKEGT IVSSNTSGIS VEDMAEDCSD DFRKHFLGTH FFNPPRYLKL LEVIPTNDTD
PEVLEFMKTF GENVLGKGVV EAKDTPNFIA NRIGTYGLLV TVQEMLKGGY SVGEVDSVTG
PMIGRPKSAT FRTLDVVGLD TFIHVAKNVY DQVEGAEKEV FDVPEFILKM QEKGWLGAKS
GQGFFLKKKD KNGSVIYELD PETLEYVDRK KLKTAATEIA KQEKGSHRKL KALVSAKGDR
AGELVWNISK PALIYSAELL GEIADDIVSI DQAMKWGFGW EHGPFEMWDA IGLRKSVERM
QEEGETVPNW VLKMLEDGNE SFYKTENGNV FFYDNGEYKQ QTFNKKEINL KQLKNVNGVI
KKNAGASLID LGDGVAGLEF HSQSNAIGPD IIQMINFALN EVDKNFEGLV IGNQGKNFCV
GANLAMMLME AQDDNFFELD MVVKQFQNAA MNIKYSNKPV VTAPFNMTLG GGAEFSLPAD
AIQASAETYM GLVEFGVGLI PGGGGTKELY LKQLRNLPKG VNFDLSKVAN DVFEKVATAK
VSTSAAEARE NGFLNSNDGI SVNPDHLLHD AKQKVLALAS AGYQAPKREK VPVVGDSGYA
AMLMGAKSLQ LSGYASEHDV KIAEKLAYVL SGGRIKEGTL VDEQVLLDLE REAFLSLIGE
RKTQERMQHM LIKGKPLRN
//
