ID A0A220UFL8_9MICO Unreviewed; 1067 AA.
AC A0A220UFL8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=CFK39_13655 {ECO:0000313|EMBL:ASK66682.1};
OS Brachybacterium avium.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermabacteraceae;
OC Brachybacterium.
OX NCBI_TaxID=2017485 {ECO:0000313|EMBL:ASK66682.1, ECO:0000313|Proteomes:UP000198398};
RN [1] {ECO:0000313|Proteomes:UP000198398}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VR2415 {ECO:0000313|Proteomes:UP000198398};
RA Tak E.J., Bae J.-W.;
RT "Brachybacterium sp. VR2415.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP022316; ASK66682.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A220UFL8; -.
DR KEGG; brv:CFK39_13655; -.
DR OrthoDB; 5240387at2; -.
DR Proteomes; UP000198398; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 31..315
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 315..613
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 52..59
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1067 AA; 113023 MW; 48E9D194C1E299D3 CRC64;
MRQTGTTTGE GIRLLGPDLE ALPALHAVEE LDDVQRAALE RFLGGGDVLV HGGPGSGRTA
LALTAAEVSG TGTLLLAPRR AAAGRLRDTL AVRGTGEVRA MTPPALGHAL VRADALRRGL
GEPTLVTGAE QDALLAELIA QRESWHLEVD PGARTLASFR TELRDLITRA AELGLTPADL
EALGHERGRP AWLDAAALLR DYLGVLDLEA SAALDAGPRL DSGALVRRAV QLLADPATPP
PFRAVVVDDA QDLTAAGIAL VSALAAAGAR VLVCSSPDAA VDTFRGALPD AAERLRETLP
RPVGSIVLTG AHAQVEGLTA AVDALRGRLP RAGAPAEARR PRASRLGALV ALRAQDPLDE
ARLIGSALRD LHHREEVDYD QMAVVCRSGA AVADLADLLS RTGLPVRIPH RPQPLREVPA
IADLLTILEI GLAPPEAPLD PRRATELLRG PFGDADTLRL RRIRRLLLSA HRAADPDSGA
TSEQLLARAL VDQDAPGLPA AAARDRAAAP VHRVRDMIAA VREHRDADAQ LVLWQAWDAS
GLAGGWRRAA LGAAGDVDGA RSRLAASRLD ALLELFAAAE RLADRRPGAG ALDLVEQVRS
QAVVEDTLAP AAAARGRIAV LTPAQLAGEH RDTVVLARLQ EGAWPDLRLR STLFGAAELS
LRVGARRGAE LPLEADAVRA LQREQVIADE LRLAVSALAR ARRRVLVTAI QDEQNEPSAL
FDALADLAAR ADSSDPEAAP WIDLKTLRRD PGPAPDARRL VAALRRRLRE EDPDSARDAA
LALEALGRAG APGTDPARWY HQEPSSTAPL HQDDDLIRLS PSALERAVDC PQSWLMERAG
GTRSGGPAQL IGTALHHLAQ VHPRGPAGGE QDLLEELHTL LRTVPGTETW SGRRRVRRAE
DAARLLSDHL RSAGEPLAVE APFEVTLGRV QLRGSIDRIE GDATGLRVVD LKSGRAAKSA
AKAEEDLQLA AYQAAVREGA LSEQLGPDAP DRLNGAELVY VGTGGKKAAV RTQGALTRAE
DPGWFDDLVQ EVSREVSGDQ VTARVNAHCT HCAVRSSCSL QPEGDQL
//
