ID A0A221NZG0_9ACTN Unreviewed; 343 AA.
AC A0A221NZG0;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:ASN24905.1};
GN ORFNames=LK07_13580 {ECO:0000313|EMBL:ASN24905.1};
OS Streptomyces pluripotens.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1355015 {ECO:0000313|EMBL:ASN24905.1, ECO:0000313|Proteomes:UP000031501};
RN [1] {ECO:0000313|EMBL:ASN24905.1, ECO:0000313|Proteomes:UP000031501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 137 {ECO:0000313|EMBL:ASN24905.1,
RC ECO:0000313|Proteomes:UP000031501};
RA Ser H.-L., Lee L.-H.;
RT "Genome sequence of Streptomyces pluripotens MUSC 137T.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR EMBL; CP022433; ASN24905.1; -; Genomic_DNA.
DR RefSeq; WP_039656274.1; NZ_CP022433.1.
DR AlphaFoldDB; A0A221NZG0; -.
DR STRING; 1355015.LK06_012450; -.
DR KEGG; splu:LK06_012450; -.
DR OrthoDB; 105475at2; -.
DR Proteomes; UP000031501; Chromosome.
DR GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR GO; GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:UniProt.
DR GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR CDD; cd01320; ADA; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR001365; A_deaminase_dom.
DR InterPro; IPR006330; Ado/ade_deaminase.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01430; aden_deam; 1.
DR PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR Pfam; PF00962; A_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000031501}.
FT DOMAIN 11..340
FT /note="Adenosine deaminase"
FT /evidence="ECO:0000259|Pfam:PF00962"
SQ SEQUENCE 343 AA; 37547 MW; F04612B1F3A91F04 CRC64;
MERVRDLSEL PKAHLHLHFT GSMRPDTLLE LADKYGVRLP DALTEALTSG EPPKLRATDE
RGWFRFQRLY DAARSCLRAP EDIRRLVREA AEEDVRDGSG WLEIQVDPTS YAPRLGGLIP
ALEIILDAVD TASRETGLGM RVLVAANRMK HPLDARTLAR LAVRYADRGV VGFGLSNDER
RGMARDFDRA FHIAREGGLL AAPHGGELTG PVSVRDCLDD LHASRIGHGV RAAEDPGLLR
QLADRGVTCE VCPASNVALG VYDKPEDVPL RTLFEAGVPM ALGADDPLLF GSRLAAQYEI
ARRHHGFTDE QLAELARQSI RACAAADDVR AKLLSGVDDW LAG
//
