ID   A0A221P0R4_9ACTN        Unreviewed;      1318 AA.
AC   A0A221P0R4;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=ATP-dependent helicase {ECO:0000313|EMBL:ASN25628.1};
GN   ORFNames=LK07_18170 {ECO:0000313|EMBL:ASN25628.1};
OS   Streptomyces pluripotens.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1355015 {ECO:0000313|EMBL:ASN25628.1, ECO:0000313|Proteomes:UP000031501};
RN   [1] {ECO:0000313|EMBL:ASN25628.1, ECO:0000313|Proteomes:UP000031501}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MUSC 137 {ECO:0000313|EMBL:ASN25628.1,
RC   ECO:0000313|Proteomes:UP000031501};
RA   Ser H.-L., Lee L.-H.;
RT   "Genome sequence of Streptomyces pluripotens MUSC 137T.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP022433; ASN25628.1; -; Genomic_DNA.
DR   RefSeq; WP_043432658.1; NZ_CP022433.1.
DR   STRING; 1355015.LK06_017015; -.
DR   KEGG; splu:LK06_017015; -.
DR   OrthoDB; 9805617at2; -.
DR   Proteomes; UP000031501; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   CDD; cd17989; DEXHc_HrpA; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR024590; HrpA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010222; RNA_helicase_HrpA.
DR   NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF11898; DUF3418; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:ASN25628.1};
KW   Hydrolase {ECO:0000313|EMBL:ASN25628.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031501}.
FT   DOMAIN          87..251
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          279..446
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1318 AA;  149562 MW;  D0B9EF1A170307DF CRC64;
     MSTHPAPAFG TLAPRLTELS LRDAHRLGRR LEGARKIRKP EARASVLAEI DAEIGKAEAR
     MAERRFRVPA VGYPAQLPVS QKKDEISAAI RAHQVVIVAG ETGSGKTTQI PKICLELGRG
     VRGMIGHTQP RRIAARTVAE RVAEELETPL GETVGWKVRF TDQVNPDATF IKLMTDGILL
     AEIQTDRELR AYDTIIIDEA HERSLNIDFL LGYLAQLLPK RPDLKVIITS ATIDPERFSR
     HFGDAPVIEV SGRTYPVEVR YRPLLEEDSE DTDRDQITAI TDAVEELMGE GPGDILVFLS
     GEREIRDTAD ALEKKKYRFT EVLPLYARLS HAEQHRVFQP HAGRRIVLAT NVAETSLTVP
     GIKYVIDPGF ARISRYSHRT KVQRLPIEPV SQASANQRKG RCGRTSDGVC IRLYSEDDFL
     ARPEFTDAEI LRTNLASVIL QMTAAGLGDI EKFPFIDPPD HRNIRDGVQL LQELGALDPV
     QKDPRKRLTD TGRKLAQLPV DPRLARMVLE ADRNGCVREV MVITAALSIQ DPRERPVEKQ
     TQADQQHARF KDETSDFLAY LNLWRYIREQ QRERGSSSFR RMCKQEYLNF LRIREWQDIY
     TQLRTVAKQM GMRFEEPSAG ADAPADRIHV SLLAGLLSHI GLKDVKDGNK NEYLGARNAK
     FAVFPGSALF RKQPRFVMSA ELVETSRLWA RVNAKIEPEW IEPLAGHLLK RTYSEPHWEK
     DQAAVMAYER VTLYGVPVVA QRKVNYGRVD PEVSRELFIR NALVEGDWRT HHKFFGANRR
     LLSEVEELEH RARRRDIVVD DDTLFDFYDQ RVPQHVVSGA HFDSWWKRKR HEQPDFLDFE
     REMLIRESAE AVTKADYPDS WRQGQLTFRV TYQFEPGADA DGVTVHIPLQ VLNQVTDTGF
     DWQIPGLREE LVTELIRSLP KPIRRNYVPA PNYAKAFLER AVPLQEPLTV TMARELKRMV
     GVPFEADDFD WAKVPDHLQI TFRIIDERRR KLAEDKDLET LRLRLKPKAR KALSQAAAAT
     ASRTGGESLE RSGLTDWTFG ALTRVFETRR AGQPVKAYPA LVDDGDTVSV RLFDTGAEQA
     EAMWKGTRRL ILRNIPVNPA KFASEKLTNQ QKLALSANPH GSIQALFDDC AMAAADQLIA
     DFGGPAWDEE SYRKLYDKVR AEIVDTTVRT VGQVQQVLAA WQSCERRLKA VSSPALLANL
     ADVRKQLDAL VKPGFVTWAG IRRLPDLMRY LVAADRRLQQ MPTGVPRDTS RMAKVHEMQD
     EYAWLLEQLP QGRPVPSSVL DIRWMIEELR VSYFAHALGT AYPISDKRIV KAIDAAVP
//