ID A0A221P287_9ACTN Unreviewed; 708 AA.
AC A0A221P287;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transcriptional regulator {ECO:0000313|EMBL:ASN26274.1};
GN ORFNames=LK07_22215 {ECO:0000313|EMBL:ASN26274.1};
OS Streptomyces pluripotens.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1355015 {ECO:0000313|EMBL:ASN26274.1, ECO:0000313|Proteomes:UP000031501};
RN [1] {ECO:0000313|EMBL:ASN26274.1, ECO:0000313|Proteomes:UP000031501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 137 {ECO:0000313|EMBL:ASN26274.1,
RC ECO:0000313|Proteomes:UP000031501};
RA Ser H.-L., Lee L.-H.;
RT "Genome sequence of Streptomyces pluripotens MUSC 137T.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
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DR EMBL; CP022433; ASN26274.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A221P287; -.
DR STRING; 1355015.LK06_021055; -.
DR KEGG; splu:LK06_021055; -.
DR Proteomes; UP000031501; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091}; Reference proteome {ECO:0000313|Proteomes:UP000031501};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 70..175
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 70..175
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 708 AA; 77403 MW; 74B6E8A9C2227830 CRC64;
MRPKRRRKSC RTRRGTLRIA KVCELTELAQ DELKILLKRY ITGASVMHHA AAVSLAKPPK
AEVAPPYIRA QQRSAGRAEP NISFQVLGPL EAWVGPRKVE IGGPRQRIVL AMLLLAPDRV
VSIDQLVEAV WNGRPPTTCR TQIAICVASL RKAFRTAGFT GELIGTSAPG YLLHLAGHHI
DSTEFAAGVD SAQTLARQGD VGAAADRLGQ ALGLWRGPVL PDMSSPVLET EAELLDHRRL
TAYEQYATLQ LQLGRHREVI AELTALVHDR PLWEQARAAL MLAHYRSGHR SEALALFRQA
QRDFRDEIGL EPGRVLQDLH TAILREASDL MPPTDTTGPL NVVTASPQLG SPEGELVGRD
SEIRSLDALL RRAREGVSSV GLVVGRPGIG KTALVLHWAR RAAHAFPDGQ LYVDFERTGT
ADAPAALLRA LGMSDPEIPR NYQDRLREFH RQIGDLRLLV ILDGVPDDNV AHDFIPKAGR
CCVLLTSRRV LATAAQVRLR VPELTPADSV TLLGSLVDDG RVEEDEAAAR RLASLCEHLP
LALSAAAARL VAKPHWRFPH LLTRLGDRRH RLEELSAGAP VLRRVLDSVY RTLSPAAADL
YARLGLINGE CIAVWEAQAL LEVGAMAAQR LLEELVDATL IEVADTGPDG WFRYRLPTLH
ALHAEETAHT EVAASVRKAA CERVLAAGTS HLKCPADSRA IPALRMVD
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