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Database: UniProt
Entry: A0A221P417_9ACTN
LinkDB: A0A221P417_9ACTN
Original site: A0A221P417_9ACTN 
ID   A0A221P417_9ACTN        Unreviewed;       442 AA.
AC   A0A221P417;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Class I SAM-dependent RNA methyltransferase {ECO:0000313|EMBL:ASN26999.1};
GN   ORFNames=LK07_26610 {ECO:0000313|EMBL:ASN26999.1};
OS   Streptomyces pluripotens.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1355015 {ECO:0000313|EMBL:ASN26999.1, ECO:0000313|Proteomes:UP000031501};
RN   [1] {ECO:0000313|EMBL:ASN26999.1, ECO:0000313|Proteomes:UP000031501}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MUSC 137 {ECO:0000313|EMBL:ASN26999.1,
RC   ECO:0000313|Proteomes:UP000031501};
RA   Ser H.-L., Lee L.-H.;
RT   "Genome sequence of Streptomyces pluripotens MUSC 137T.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01024}.
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DR   EMBL; CP022433; ASN26999.1; -; Genomic_DNA.
DR   RefSeq; WP_043434898.1; NZ_CP022433.1.
DR   AlphaFoldDB; A0A221P417; -.
DR   STRING; 1355015.LK06_025450; -.
DR   KEGG; splu:LK06_025450; -.
DR   OrthoDB; 9804590at2; -.
DR   Proteomes; UP000031501; Chromosome.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0001510; P:RNA methylation; IEA:GOC.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 2.40.50.1070; -; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR030391; MeTrfase_TrmA_CS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002792; TRAM_dom.
DR   InterPro; IPR010280; U5_MeTrfase_fam.
DR   PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11061:SF30; TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE; 1.
DR   Pfam; PF01938; TRAM; 1.
DR   Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR   PROSITE; PS50926; TRAM; 1.
DR   PROSITE; PS01231; TRMA_2; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU01024}; Reference proteome {ECO:0000313|Proteomes:UP000031501};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01024};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU01024}.
FT   DOMAIN          7..68
FT                   /note="TRAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50926"
FT   ACT_SITE        395
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT   BINDING         271
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT   BINDING         300
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT   BINDING         324
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT   BINDING         368
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
SQ   SEQUENCE   442 AA;  47935 MW;  00729CA0AF5D6A30 CRC64;
     MQAEPTKSLV GEEYEVEIGP VAHGGHCIAR TTEGQVLFVR HALPGERVVA RVTEGEEGAR
     FLRADAVRIL EAAKDRIAAP CRFAGPGRCG GCDWQHAKPG AQRRLKAEVI AEQLKRLAGL
     SPEEAGWDGT VVPAEGDKLP SGQVPQWRTR VQYAVDAEGH AGLRRHRSHE VERIDHCMIA
     AEGVSELGIE KRDWSGMESV EAIAATGSQD RQVILTPRPG ARLPLVELDK PVSVLRVDEK
     SGGVHRVHGR PFVRERADGR TYRVGNGGFW QVHPKAADTL VTAVMQGLLP RKGETALDLY
     CGVGLFAGAL ADRLGEKGAV LGIESGKRSV EDARHNLADF PRVRIEQGKV ESVLPRTGIT
     EVDLIVLDPP RAGAGRRTVE HLSSLGARRI AYVACDPAAL ARDLGYFRDG GYRVRTLRAF
     DLFPMTHHVE CVAILEPAAK GS
//
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