ID A0A221P4X6_9ACTN Unreviewed; 520 AA.
AC A0A221P4X6;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=4-hydroxyphenylacetate 3-hydroxylase {ECO:0000313|EMBL:ASN27146.1};
GN ORFNames=LK07_27490 {ECO:0000313|EMBL:ASN27146.1};
OS Streptomyces pluripotens.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1355015 {ECO:0000313|EMBL:ASN27146.1, ECO:0000313|Proteomes:UP000031501};
RN [1] {ECO:0000313|EMBL:ASN27146.1, ECO:0000313|Proteomes:UP000031501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 137 {ECO:0000313|EMBL:ASN27146.1,
RC ECO:0000313|Proteomes:UP000031501};
RA Ser H.-L., Lee L.-H.;
RT "Genome sequence of Streptomyces pluripotens MUSC 137T.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP022433; ASN27146.1; -; Genomic_DNA.
DR RefSeq; WP_052269661.1; NZ_CP022433.1.
DR AlphaFoldDB; A0A221P4X6; -.
DR STRING; 1355015.LK06_026335; -.
DR KEGG; splu:LK06_026335; -.
DR OrthoDB; 9785230at2; -.
DR Proteomes; UP000031501; Chromosome.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR Gene3D; 1.10.3140.10; 4-hydroxybutyryl-coa dehydratase, domain 1; 1.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 1.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR InterPro; IPR004925; HpaB/PvcC/4-BUDH.
DR InterPro; IPR024719; HpaB/PvcC/4-BUDH_C.
DR InterPro; IPR024674; HpaB/PvcC/4-BUDH_N.
DR PANTHER; PTHR36117; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR PANTHER; PTHR36117:SF3; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR Pfam; PF03241; HpaB; 1.
DR Pfam; PF11794; HpaB_N; 1.
DR PIRSF; PIRSF000331; HpaA_HpaB; 1.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR000331-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000031501}.
FT DOMAIN 5..272
FT /note="HpaB/PvcC/4-BUDH N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11794"
FT DOMAIN 299..480
FT /note="HpaB/PvcC/4-BUDH C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03241"
FT REGION 491..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..509
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 149..151
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
FT BINDING 192
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
FT BINDING 455..458
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
SQ SEQUENCE 520 AA; 57783 MW; C486C6FFD0EC06E7 CRC64;
MPARTGKQYL DHLKSLNPEI YLNGRRIAHV TEEPVFAGPL RTIAEQYDLQ LDPRYVDVCT
YVSPTTGERL SRSFQPCRSK EDLVAKRRHF KLRADHTFGM MGRSPDFMNA FVLGWNTNAP
VFGELDERFG ENARRYYEHV RDNDLFLTHV LINPAIDRSK TSAQQEDPFL HLGKVRETDG
GIVVRGAKML STMAPFAEEL VVVPFGGIAP GDDDYAVVFA IPIDTPGLKF ICREPVAPAG
RTEFDHPLSS RFEEMDCIAV FDDVLVPWDR VVVDGRPGSR DLVNRVLGND PSVLVVNGAR
SLASSELLCG IATKIADATG IDGFLHVQEK LGDLVSRLET LRTLFYGAEA LAAPLRDGTW
VPYMPGMMAF LMQTAPTHRR MVEVIQILAA GNFFYAPSSG DFANEELRPF IDRFVRGRPG
IPAQERVRLF KLAWDVAGDG FGQRLMQYVN YYSGDPVRLT AGLYLGADKT EIHRTVERAL
AGSDRSLDIP LSPEVLEMAP PPPPTKPLTG MYPAKSQPSA
//
