ID A0A221P5V5_9ACTN Unreviewed; 4277 AA.
AC A0A221P5V5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:ASN27641.1};
GN ORFNames=LK07_30450 {ECO:0000313|EMBL:ASN27641.1};
OS Streptomyces pluripotens.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1355015 {ECO:0000313|EMBL:ASN27641.1, ECO:0000313|Proteomes:UP000031501};
RN [1] {ECO:0000313|EMBL:ASN27641.1, ECO:0000313|Proteomes:UP000031501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 137 {ECO:0000313|EMBL:ASN27641.1,
RC ECO:0000313|Proteomes:UP000031501};
RA Ser H.-L., Lee L.-H.;
RT "Genome sequence of Streptomyces pluripotens MUSC 137T.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP022433; ASN27641.1; -; Genomic_DNA.
DR STRING; 1355015.LK06_029280; -.
DR KEGG; splu:LK06_029280; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000031501; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000031501};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 19..436
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 924..999
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1016..1441
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2630..2705
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2727..3152
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4135..4210
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 4107..4126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4277 AA; 443544 MW; 091EBB61A082C2B5 CRC64;
MAGGGGNPVG NRVGDATSQE PVAVVGLACR LPGAANPAEL WQLLRDGRDA LSEPGPRRCH
PDGPVAPVLP SGQPIRAGFL EQVDLFDAGF FGVSPGEAAV LDPQQRLVLE LAWEAFEDAG
IIPGDGQSGT AHGTGVYVGA TYDDYAALRG ARLSPHSATG RNRGMIANRV SYALGLRGPS
LVVDSAQSSA LVAVHLACRA LSAGECAVAL AGGVNLNIGQ DGYDITQALG AISPDGHCYT
FDERANGFVR GEGGAVLVLK PLAAALADGD TVHAVIRGSA TNNDGGGETL TAPRQEAQQA
VLRLACTAAG VSPAELSYVE LHGTGTPLGD PVEAAALGAV TRRERPLLVG SVKTNIGHLE
GAAGIAGLLK TVLCLSRREL VPSLNFRTPN PRIPLAELGL RVVTETGPWP AVEGPLLAGV
SSFGMGGANC HVVLSEPPAS GAASDRASGR YDGPVLVPLS ARTPPALAGL AALLGESAAS
PVDLAYSLAT TRSTLEQRAV LVAESAGEVP GLLAKLARGE AGARVVRGTA VEGRTVFLFP
GQGNQRPGMG REIYRRYPVF AAAVDEIAEH TRPHLPRPLL EVVFAEQGSA DAALLEQSTY
TQPALFAVQV GLFRLVESWG ITPDAVLGHS FGELAALHVA GAMSLADACT LAATRGRLMH
EIPPGGAMVL VEASEAELLA DVGASGGLVS IAALNSPTAT VLSGDEDATL AIAGHWSARG
RRTRRIQVPM ASHSAHVDAI LDGMRAAAAQ IGWRRPSLPV LSSLTGAELD VVELDWPEFW
ARHTRNTVRF ADAIATACAR GARTFLELGP DGTLCAMGPG SAPPDVAFVS ALAGGERPDL
RSLLTAVARL HTRGVPVDWA RFYAGCGAQR IPLPTYPFQR RRHWIAGVTA TGGAVPAPVG
APVAEAPTRP VSRLAGLPAA EREQAVHALV RAEVAAALEL DSAGELEVRR PFKDLGFGSL
MTVELAQRLA EATGLRLPAT AVLDHPTPER IAGHLIAELA AGTPAESAPA AATPAVEPIA
IVGMACRFPG GVGSPEELWD LVLRGGDAVG AFPTDRGWDL DGLFDEDPDR PGRSYARTGG
FLYAAAEFDA GLFGISPREA LAMDPQQRLL LETSWEALER AGIDPLALRD SGTGVFVGAM
AQDYGPRMHE GAAGLDGYVL TGTTASVASG RIAYSLGLRG PAVTVDTACS SSLVALHLAA
QALRAGECSL ALAGGVTVMS TPGIFVEFSR QRGLAPDGRC KSFAAAADGT GWAEGAGQLV
LERLSDARAN GHPVLAVLRG SAVNQDGASN GLTAPNGPAQ EGVIRSALAS AGLSASDVDL
VEAHGTGTAL GDPVEANALL AAYGRNRTGE PLWLGSLKSN IGHTQAAAGV AGVIKVVQAL
RHGLLPRTLH VEEPSPYVDW SAGGVRLLTE ERPWPGGERP RRAGVSSFGI SGTNAHVVIE
QAPGAAAQTT VEPTAEPVAV LRPGPVPVVV SGQSATALRA QAERLAAHLE RQPESPLEDV
ARAAATTRAG LQHRAVLTAT DRADLIRGLR TLAADEESPV LVRGAADVAG RTVFVFPGQG
AQWAGMAVEL LESSAVFAAR MAECASALGE FVDWSLLGVL RGEAGEPALD RVDVVQPVSF
AVMVSLVALW RSFGVEPDAV VGHSQGEIAA ACVAGALSLR DAAKVSALRS AALSELSGAG
GMMSVALPVT ELEPRLAVRA DRVSVAAVNG PASVVLSGEP GPLRELAAEL TAEGVRARLV
AVDYASHSPQ VERIRAELLD RLAGLRPRSA EVPFYSTVTG ERLDTATLDA EYWYRNLRQT
VRFEQTIREL DRAGHRVFVE ASPHPILTAA VQDSVESAGS TAVVVGSLRR DQGGPGRFLL
SLAEAYVRGV PVDWTAAFGV AGHRAELPTY AFQRERYWLS TPVLGTDPAG FGLDATEHPL
LGAAAPVAST GEVLLTGELS LQRQPWLADH TVFGTVVLPG TAFVELAVRA GDEAGCPVLE
ELTVHAPLPL PERGAVRLQV VLGAPGEDGG RAVDVYSRPG SGPQWTHHAT GRLGVAEVPA
PAPGGWLPEG ATPIELTDRY PALARLGYGY GPVFQGLSRL WRHGEELFAE IALPEPAAGE
AGSFGLHPAL LDAALHAAIP VDDTTGPAST TVLPFAFNGV RLYRAGATAA RVRLRTQAEG
VVSITVTDAE DNPVTVIDSL AFRPVTTEQL TAGRRDHLYR IGWVPLAAPA QDGAWVSLGD
PAGLDALGDR VPAVVGLAVT GVTDALAVAQ RWSAEERFAG SRLVLLTRGA VTVGPGEPPV
DPDAAAVWGL LRSAQTENPD RFVLADTDGH AASEALLPRL AGTGEGQLAV RAGRVLVPRL
ARVAEVPGGS PWSVDGTVLI TGASGTLGRL VARHLVGRHG VRGLVLVSRR GGDAPGMAEL
VAELRGWGAE VAVVACDVAE RDAVAALLAE HPVTAVVHAA GILDDGVLAA LTPQRVARVF
RAKVDGARHL AELTGPELTA FVLFSSVAGT LGNAGQAAYA AANAALDALA ARRRAAGLPA
TAVAWGLWAE SSGMTGQMAD TDRARLARAG MLPLDSATAL EAFDAATALD DPVLLAARLD
PVALRERAAE GVLSPVLRGL VPVVRRAAAG GAVDGADGLR RRLAEGEPLR VLQDLVLTQA
AVVLGHSDSS GLLPDRPFKD IGFDSLTAVE LRNRLGRATG VRLPATVVFD HPTPAGLARY
LVGELVGAGR PTAASAAASP ATAEAADEPI AIVGMACRFP GGIASPEDLW NLVASGGDAI
GGFPTDRGWD VAGLYDPDPD RAGHTYTRHG GFLYDAGRFD AGLFGISPRE ALAMDPQQRL
LLETAWEALE RAGIDPSSVR GTRTGVFTGV MYHDYATMLR ELPEGVEGHL LTGTAASVAS
GRVAYTFGFQ GPAITVDTAC SSSLVALHLA AQALRSGECS LALAGGVAVM AEPTTFTAFS
RQRGLAADGR CKSFAGAADG TGWSEGVGLL LLEPLSAAHR NGHRVLAVVR GSAVNQDGAS
NGLTAPNGPS QERVIRAALA AAGLSAQDVD AVEGHGTGTP LGDPIEAQAL LATYGRNRDG
DPLWLGSVKS NIGHAQAAAG MAGVIKVVQA LRHGVLPRTL HVDEPSAHVD WSAGGVRLLT
EERPWPDTGH PRRAGVSSFG ISGTNAHVIV EQAEAVEAEA VRTDAAQAVE RPEAVQDGGA
GTARRETEPR MLPVALSGQT EDALRGQAAR LAAHLADHPG DRVLDIAWSS VAGRAALEHR
AVVLAADPDQ LGERLGALAE GRDTPGVLRG TAAGAARRVA FVFPGQGAQW AGMALELLDS
VPVFAARLAE CAAAIEAHVD WSDWSVLDVL RGTPGAPALD RVDVVQPVTF AVTVSLAALW
RAHGVEPEAV IGHSQGEIAA ACVAGALSLA DAAAVVCLRS RALTELSGKG GMMSVALPAD
EVRALFADDR LGVAAINSPT STVVSGDPSA LEELWAVCES RGVRARRVAV DYASHSTQVT
AVEDSLNALL AGISPQAARV DWYSTVTGQR LDTRELTGAY WYTNLRQTVR FADAVRAALD
AGIGTFLEIS PHPVAAPGVQ ETVDAAGARA TVLSTLRRDD GGWPRFAQSL AEAHVRGAGV
RLAEVFAGTG ARSVDLPTYA FQHRWYWLAE QARSRSDSWR YRVEWRAAGA PERTGPDGEW
LALVPGSGAQ QDWLQTLIGG LPVRTITVDT EHADRADLTG QLRRALAEHA PCGVLSLLAA
DRRPHPEHPV VPAGVAATLA VVQALGDLAA AVPLWLVTSG AVSTGDDDRL REPSAAQVWG
LGRVAMLEHP AFWGGLVDLP AELDEAALEQ VRGVLAGGWG EEDQLAVRAS GTLLRRLVHA
PPAGGAVSDW QARDTAIVTG GTGALGPEVA RWLAGLGARH VVLVSRSGPD AEGVAELADE
LDGLGVRLTA RACDMGDRAA VAALLAGLRE QGEVVRTVVH AAALMRLAAL PETDLAEYAD
ALTAKVQGAR HLVELLDPVE LDALVFYSSI AAVWGSGDHG AYAAANAELD ALAEQARAAG
LPVTSVAWGV WDGARFPDGV DAGQLRRQGL PLIAPGPALD ALRTILERAE VGLAVADVDW
ATFMPLFTSA RSRPLFAEIP EARSALRGAT APEAQPSGSS WSQRLAGLSD TERRSTLLRL
VRDQAAVVLG HSSTAAIGAD RAFRDLGYDS LTGIELRNRL GETTGLTLPA TLVFDHPTAA
AVAAYLHSRL APVEPPILTE LDRLSERLSR ADTDGERAGI ELRLRAMLSL IGGDDDDFDP
ASNEEMYDLI DRELGAN
//
