ID A0A221P606_9ACTN Unreviewed; 684 AA.
AC A0A221P606;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:ASN27526.1};
GN Name=shc {ECO:0000313|EMBL:ASN27526.1};
GN ORFNames=LK07_29780 {ECO:0000313|EMBL:ASN27526.1};
OS Streptomyces pluripotens.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1355015 {ECO:0000313|EMBL:ASN27526.1, ECO:0000313|Proteomes:UP000031501};
RN [1] {ECO:0000313|EMBL:ASN27526.1, ECO:0000313|Proteomes:UP000031501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 137 {ECO:0000313|EMBL:ASN27526.1,
RC ECO:0000313|Proteomes:UP000031501};
RA Ser H.-L., Lee L.-H.;
RT "Genome sequence of Streptomyces pluripotens MUSC 137T.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene synthase family.
CC {ECO:0000256|ARBA:ARBA00006333}.
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DR EMBL; CP022433; ASN27526.1; -; Genomic_DNA.
DR RefSeq; WP_039655453.1; NZ_CP022433.1.
DR AlphaFoldDB; A0A221P606; -.
DR STRING; 1355015.LK06_028610; -.
DR KEGG; splu:LK06_028610; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000031501; Chromosome.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000031501};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 43..327
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 338..654
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 75436 MW; 984064AC670111C0 CRC64;
MTATTDGSTG ATLPSRATAA SDTTLITPEA AAGAGEAAAR AARRATEFLL SRQDVQGWWK
GDLETNVTMD AEDLLLRQFL GIREEATTQA AAVFIRGEQR EDGTWATFFG GPGELSTSIE
AYVALRLAGD EPDAPHMAKA SAWIREHGGI AASRVFTRIW LALFGWWKWE DLPELPPELI
YFPSWMPLNI YDFGCWARQT IVPLTVVSAK RPVRPAPFPL DELHTDPDTP NPPKPLAPVA
SWDGAFQRLD KMLHQLRKVA PRGLRKAAMN SAARWIIERQ ENDGCWGGIQ PPAVYSVIAL
HLLGYDLQHP VMREGLASLD RFAVWREDGA RMIEACQSPV WDTCLAVIAL ADAGLPTDHP
QLVKAADWML GEEIVRPGDW AVKRPQLPPG GWAFEFHNDN YPDIDDTAEV ALALRRVRHH
DPERVDRAIG RAVRWNLGMQ SKNGAWGAFD VDNTSSFPNR LPFCDFGEVI DPPSADVTAH
VVEMLAAEGL AHDPRTRRGI AWLLAEQEPN GAWFGRWGVN YLYGTGSVVP ALTAAGLPVA
HPAIRKAVAW LESVQNDDGG WGEDLRSYQQ AEEWSGRGVS TASQTAWALM ALLAAGERDS
TAVERGIQWL AGTQREDGTW DEPYFTGTGF PWDFSINYHL YRQVFPLTAL GRYLHGDPFE
RQLLARAGQP PARAGRPLSE ARGS
//
