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Entry: A0A221Q335_9MICC
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ID   A0A221Q335_9MICC        Unreviewed;       370 AA.
AC   A0A221Q335;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   31-JUL-2019, entry version 8.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=CGQ24_05690 {ECO:0000313|EMBL:ASN38550.1};
OS   Arthrobacter sp. 7749.
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=2020130 {ECO:0000313|EMBL:ASN38550.1, ECO:0000313|Proteomes:UP000199762};
RN   [1] {ECO:0000313|EMBL:ASN38550.1, ECO:0000313|Proteomes:UP000199762}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7749 {ECO:0000313|EMBL:ASN38550.1,
RC   ECO:0000313|Proteomes:UP000199762};
RA   Sastre D.E., Santos L., Kagohara E., Andrade L.H.;
RT   "Draft Genome Sequence of a Psychrotrophic Arthrobacter sp. Strain
RT   7749, Isolated from an Antarctic Marine Sediment with Applications in
RT   Enantioselective Alcohol Oxidation.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP022462; ASN38550.1; -; Genomic_DNA.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000199762; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199762};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199762};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       54    358       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   370 AA;  38593 MW;  C03843A8ADBC1289 CRC64;
     MSTNISPAVK EQPRFNTNER ITSITELPTP AELITELPVG DAQGYRIMRA RQEVRAVLSG
     LDQRLLVIIG PCSIHDPVAG LEYAAKLAAA AKTHEGELLV VMRSYFEKPR TTVGWKGLVN
     DPHLDGSHDM AAGLRAAREF TLAASNLGLP LATEFLEPLS AQYLADVMSW GAIGARTTES
     QTHRQLVSGL SMPVGFKNGT DGSVQVAIDA CQAASAPQSF LGISDDGRTA IVATTGNQDS
     HLILRGGADG PNYGAEQVAA ASAAIAGSGM NPRLIVDASH ANSGKSEVRQ AEVIGELAAR
     IAAGDQSIAG IMAESFLVAG AQKHDPDAVA VGADVLGGLR YGQSVTDACM NWETSSDLLD
     TLAAAVRAAR
//
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