ID A0A221SY17_9DEIO Unreviewed; 334 AA.
AC A0A221SY17;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569, ECO:0000256|RuleBase:RU366046};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189, ECO:0000256|RuleBase:RU366046};
GN ORFNames=DFI_11385 {ECO:0000313|EMBL:ASN81520.1};
OS Deinococcus ficus.
OC Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=317577 {ECO:0000313|EMBL:ASN81520.1, ECO:0000313|Proteomes:UP000259030};
RN [1] {ECO:0000313|EMBL:ASN81520.1, ECO:0000313|Proteomes:UP000259030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-FR2-10 {ECO:0000313|EMBL:ASN81520.1,
RC ECO:0000313|Proteomes:UP000259030};
RA Wu K.-M., Liao T.-L., Liu Y.-M., Young C.-C., Tsai S.-F.;
RT "The complete genome sequence of Deinococcus ficus isolated from the
RT rhizosphere of the Ficus religiosa L. in Taiwan.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083,
CC ECO:0000256|RuleBase:RU366046};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911,
CC ECO:0000256|RuleBase:RU366046};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|RuleBase:RU366046}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU366046}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637, ECO:0000256|RuleBase:RU366046}.
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DR EMBL; CP021081; ASN81520.1; -; Genomic_DNA.
DR RefSeq; WP_027463192.1; NZ_CP021081.1.
DR AlphaFoldDB; A0A221SY17; -.
DR STRING; 317577.GCA_000419625_01648; -.
DR KEGG; dfc:DFI_11385; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000259030; Chromosome.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU366046};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Isomerase {ECO:0000256|RuleBase:RU366046};
KW NAD {ECO:0000256|RuleBase:RU366046};
KW Reference proteome {ECO:0000313|Proteomes:UP000259030}.
FT DOMAIN 4..257
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 334 AA; 36287 MW; 3EDFE3870732567C CRC64;
MKLLVVGGAG YIGSHTVRQL RRAGHEAVVF DNLSSGHAQA VPDGVTLVRG DLLNPADIRA
ALDAHQPDAV IHFAALIEVG ESMRAPGRYY RNNVTGSLNL LQAIVDTRKI PLVFSSTAAV
YGTTDAVPIP ENAAMQPESV YGETKLMTER MIHAFHVAHG LPYTILRYFN VCGAAPEGDI
GEAHPNKTHL IELACLTALG QREKMMVFGT DYPTPDGSCI RDYVHVQDLA DAHVLAVEAL
HAAHARGQAG QATYNVGLGH GFSVLEVLDA VDRVTGTPLH REVAPRRAGD PPRLVADATR
IVRDLGFTPQ FTDLDEIVRT AWNWHRTHPD GFRR
//
