ID   A0A222E103_9RHOB        Unreviewed;       355 AA.
AC   A0A222E103;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Homoisocitrate dehydrogenase {ECO:0000313|EMBL:ASP19648.1};
DE            EC=1.1.1.87 {ECO:0000313|EMBL:ASP19648.1};
GN   Name=hicd {ECO:0000313|EMBL:ASP19648.1};
GN   ORFNames=ANTHELSMS3_00932 {ECO:0000313|EMBL:ASP19648.1};
OS   Antarctobacter heliothermus.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Antarctobacter.
OX   NCBI_TaxID=74033 {ECO:0000313|EMBL:ASP19648.1, ECO:0000313|Proteomes:UP000203589};
RN   [1] {ECO:0000313|EMBL:ASP19648.1, ECO:0000313|Proteomes:UP000203589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMS3 {ECO:0000313|EMBL:ASP19648.1,
RC   ECO:0000313|Proteomes:UP000203589};
RA   Topel M., Pinder M.I.M., Johansson O.N., Kourtchenko O., Godhe A.,
RA   Clarke A.K.;
RT   "Genome Sequence of Antarctobacter heliothermus Strain SMS3 Isolated from a
RT   culture of the Diatom Skeletonema marinoi.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP022540; ASP19648.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A222E103; -.
DR   KEGG; aht:ANTHELSMS3_00932; -.
DR   OrthoDB; 9767905at2; -.
DR   Proteomes; UP000203589; Chromosome.
DR   GO; GO:0047046; F:homoisocitrate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR   PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   PROSITE; PS00470; IDH_IMDH; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:ASP19648.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000203589}.
FT   DOMAIN          3..348
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   355 AA;  36634 MW;  2D62E6226C82996A CRC64;
     MTRLLVLEGD GIGPEIVAAT CDVLAVLDAR FNLGLIVERA EIGFPALAAH GTTIPDAVIA
     RALEADGVIL GPVSHNAYPP VSEGGLNPSG VLRKRLDLYA NIRPARTPEG LGGRAPVDLV
     VVRENTEGFY ADRNMAEGSG EFLPEPGMAL AIRKITAKAS RRIAQSAFAL AETRPARRVT
     VVHKANVLRL SDGLFLDEVR KVAADHPEIT VDEMLVDAAA AHLVRAPERF DVIVTTNMFG
     DILSDLASEL AGSLGLGGSL NAGETRAMAQ AQHGSAPDIA GTGAANPGSL IASVAMLLHW
     LAGRGGADSF ARAGAATDAA LAVALADPAA RTPDIGGTGT TRAMTDRVIQ ALGSD
//