ID A0A222EPR9_9MOLU Unreviewed; 806 AA.
AC A0A222EPR9;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=protein-N(pi)-phosphohistidine--D-fructose phosphotransferase {ECO:0000256|ARBA:ARBA00012799};
DE EC=2.7.1.202 {ECO:0000256|ARBA:ARBA00012799};
GN Name=fruA {ECO:0000313|EMBL:ASP28442.1};
GN ORFNames=SCORR_v1c06700 {ECO:0000313|EMBL:ASP28442.1};
OS Spiroplasma corruscae.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=216934 {ECO:0000313|EMBL:ASP28442.1, ECO:0000313|Proteomes:UP000203229};
RN [1] {ECO:0000313|EMBL:ASP28442.1, ECO:0000313|Proteomes:UP000203229}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC-1 {ECO:0000313|EMBL:ASP28442.1,
RC ECO:0000313|Proteomes:UP000203229};
RA Tsai Y.-M., Lo W.-S., Kuo C.-H.;
RT "Complete genome sequence of Spiroplasma corruscae EC-1 (DSM 19793).";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] = D-
CC fructose 1-phosphate(in) + L-histidyl-[protein];
CC Xref=Rhea:RHEA:49252, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:9746,
CC ChEBI:CHEBI:29979, ChEBI:CHEBI:37721, ChEBI:CHEBI:58674,
CC ChEBI:CHEBI:64837; EC=2.7.1.202;
CC Evidence={ECO:0000256|ARBA:ARBA00001401};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP022535; ASP28442.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A222EPR9; -.
DR KEGG; scou:SCORR_v1c06700; -.
DR OrthoDB; 9782569at2; -.
DR Proteomes; UP000203229; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR GO; GO:0022877; F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR CDD; cd00211; PTS_IIA_fru; 1.
DR CDD; cd05569; PTS_IIB_fructose; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR InterPro; IPR002178; PTS_EIIA_type-2_dom.
DR InterPro; IPR036095; PTS_EIIB-like_sf.
DR InterPro; IPR013011; PTS_EIIB_2.
DR InterPro; IPR003501; PTS_EIIB_2/3.
DR InterPro; IPR013014; PTS_EIIC_2.
DR InterPro; IPR004715; PTS_IIA_fruc.
DR InterPro; IPR003353; PTS_IIB_fruc.
DR InterPro; IPR006327; PTS_IIC_fruc.
DR NCBIfam; TIGR00829; FRU; 1.
DR NCBIfam; TIGR00848; fruA; 1.
DR NCBIfam; TIGR01427; PTS_IIC_fructo; 1.
DR PANTHER; PTHR30505; FRUCTOSE-LIKE PERMEASE; 1.
DR PANTHER; PTHR30505:SF0; FRUCTOSE-LIKE PTS SYSTEM EIIBC COMPONENT-RELATED; 1.
DR Pfam; PF00359; PTS_EIIA_2; 1.
DR Pfam; PF02302; PTS_IIB; 1.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
DR SUPFAM; SSF52794; PTS system IIB component-like; 1.
DR PROSITE; PS51094; PTS_EIIA_TYPE_2; 1.
DR PROSITE; PS51099; PTS_EIIB_TYPE_2; 1.
DR PROSITE; PS51104; PTS_EIIC_TYPE_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 288..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 623..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..145
FT /note="PTS EIIA type-2"
FT /evidence="ECO:0000259|PROSITE:PS51094"
FT DOMAIN 164..259
FT /note="PTS EIIB type-2"
FT /evidence="ECO:0000259|PROSITE:PS51099"
FT DOMAIN 284..648
FT /note="PTS EIIC type-2"
FT /evidence="ECO:0000259|PROSITE:PS51104"
SQ SEQUENCE 806 AA; 87934 MW; 607D77C895B23DFA CRC64;
MNIKNTYVFL ETEFINKVDL LNFISKKALE NKITDDSKIL FESFLSREKE ASTGFEDGFA
IPHAKIKNIK EPSVIIVKNK IGIEWDSLDG KPTSYIISLI IPDNANEEHL NLLSSIATKL
TKEDFKKDFI IAKDPNELKK VLVKGYEGLG AKKVIKKNKH KLNIVAVTAC VVGVAHTYIA
EERLLEKYTN EGHKIRVETQ GSKGIGTKLT PKEIEEADLV IIATDTNVDK SRFAGKKLFE
SKIAKAVKDP LKLLDEALAN AKIYNEASGE FSNKNGVYKQ NQGVIKHILA GISYMIPIII
LGGICLAASL GIAKAIWGPS AGTSGPNDAY PWNPLAVMDK IGSAAFALMI PILAAFIANS
IGGRAAIAPA LVGGYIGNNS SFFMPLPGMP DVRTPMGFIG AIVAGLLIGY FTRWVNTWKV
PKSLKAAMPI FFIPIVGGVG ISVLFIYVIG GPIGWVMEQF SNAISKAYSS ETIGLGLGLG
LGVILGTMAA FDMGGPINKI AFVTCVALLS NSEHPIAEPM GALAAGIPVA PLGMGLTSLL
FRRFFDEQER SMGASAFIMG MIGISEGAIP FAIRDPKRAI TCNVLGGALA GGIAGSFRIQ
DNAGHGGPIV AILGAVPYGQ QTVIFLIAIA CGTLLTGFLY GFWLLSEKGT IGSLKEAYVM
YTEKTKSDYN ELFLEIKNEI KIDKKNNDAK NRDKLYKKLA DKELELKNKL LVAKTAFNEI
KVNDKNHTVS EKPNTKKYFL DIKTNKANKL KELTQITVYN SSDKKEINKL FKKQKNDIIK
NYKDQYLNKK IDLHIKYVKE FSNRVN
//
