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Database: UniProt
Entry: A0A222FDH7_9RHOB
LinkDB: A0A222FDH7_9RHOB
Original site: A0A222FDH7_9RHOB 
ID   A0A222FDH7_9RHOB        Unreviewed;       485 AA.
AC   A0A222FDH7;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=CHH27_26315 {ECO:0000313|EMBL:ASP37135.1};
OS   Labrenzia sp. VG12.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Labrenzia.
OX   NCBI_TaxID=2021862 {ECO:0000313|EMBL:ASP37135.1, ECO:0000313|Proteomes:UP000214862};
RN   [1] {ECO:0000313|EMBL:ASP37135.1, ECO:0000313|Proteomes:UP000214862}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VG12 {ECO:0000313|EMBL:ASP37135.1,
RC   ECO:0000313|Proteomes:UP000214862};
RA   Rehman Z.U.;
RT   "Annotated genome sequence of Labrenzia isolated from Red Sea.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP022529; ASP37135.1; -; Genomic_DNA.
DR   KEGG; labr:CHH27_26315; -.
DR   KO; K02313; -.
DR   Proteomes; UP000214862; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000214862};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000214862}.
FT   DOMAIN      179    308       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      393    462       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     187    194       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   485 AA;  54151 MW;  0C41643C4745A032 CRC64;
     MQVQNLAGSD QWDRVKKELR NELGDDVFSN WFGRVNHEET TGDAVRLSVP TRFLKNWIQS
     NYEKQLVGLW KREQDDIKRI ELTVRGALRP RRITAGNAPK AITARRISGR PGPFSSTPQF
     GAGAAVIPCL ADTGEEAAAD FLNGAALNPK LTFDTFAEGS SNSLACAAVR QMAAGHEGTL
     DMLYIHSTTG IGKTHLLQAA ASEARKTGRQ VAYLSAEFFM YHLVPALRTP AFPVLRQAMR
     SIDLLLVDDL QFLHGKQGQD EFAKTLEMLM EAPSQIIMAA DRSPDELDTL GEALRRRIQK
     GEVVGIQATD YALRHDILKK RVSAARRTHP GFSVPEEVSD YIARYVISSA RDLEGALNRL
     FAHNQLTKQP VTMDLAEKTL HDLVRIGEPR SIKVEEIQQV VCKHFSVTKA DLLSSCRART
     LVRPRQIAMY IAKVMTGRSL PEIGRRFGNR DHTTVLHAVR KIEDMVSKDK TLSQEVELLK
     RLVHT
//
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