ID A0A222P4L5_9GAMM Unreviewed; 725 AA.
AC A0A222P4L5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=uvrD {ECO:0000313|EMBL:ASQ46767.1};
GN ORFNames=clem_11105 {ECO:0000313|EMBL:ASQ46767.1};
OS Legionella clemsonensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=1867846 {ECO:0000313|EMBL:ASQ46767.1, ECO:0000313|Proteomes:UP000201728};
RN [1] {ECO:0000313|Proteomes:UP000201728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC-D5610 {ECO:0000313|Proteomes:UP000201728};
RA Florea S., Webb J.S., Jaromczyk J., Schardl C.L.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP016397; ASQ46767.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A222P4L5; -.
DR KEGG; lcd:clem_11105; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000201728; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000201728}.
FT DOMAIN 6..284
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 285..563
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 725 AA; 81929 MW; 7282768B88A2F1A4 CRC64;
MTALLKELNE KQREAVAAPL GSTLVLAGAG SGKTRVLVSR IAWLIEQEHI SPHAILAVTF
TNKAAGEMKA RLTSMLEIPL TGLWVGTFHG LCHRLLRRHY DAAKLPEQFH ILDSEDQARV
IKRVLASLNL DEDQWPVKQA QAFINGQKDE GLRPEHIPVL SYGPTRTLVQ IYKAYEQACQ
TAGVIDFAEL LLRTHELLRD NPDILLHYRH RFQAILVDEF QDTNTIQYAW IRLLAGEHAA
VMAVGDDDQS IYGWRGAKVE NIQRFSQDFR NTQLIRLEQN YRSTSTILDA ANALITNNNS
RMGKNLWTAG KAGEKIVVYS AFNELDEARF LGERIVMEIN NGRSADEIAI LYRSNAQSRV
IEEALLRAGI AYRIYGGVRF FERAEVKDTL AYLRLIANPY DDTAFERIVN FPTRGIGEKT
LEELRHLAKA EDISLWQAAN AVLQAKQLPQ RAATALTKFI ELIETLQRQT VHQELDEQIG
TVIECSGLYA HFAKIKGDKA ESRLDNLQEL VNAAKQFRYE QEIDEELPLL VAFLAHASLE
AGEMQAEAHE RSVHLMTLHA AKGLEFPLVF LAGMEEGVFP SKQSLEEAGR LEEERRLCYV
GMTRAMEKLI MSYAEVRRQY GREEYHRRSR FLRELPEELL DEVRVKARFQ APLSPKTLSS
VAAEEVGLKL GQNVSHPKFG HGVILAVEGS GAHTRVQVKF ADHGAKWLVL AYANLTPHED
YVPFN
//