ID A0A222SKA8_9CHLB Unreviewed; 447 AA.
AC A0A222SKA8;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
GN ORFNames=CHL67_09945 {ECO:0000313|EMBL:ASQ91190.1};
OS Prosthecochloris sp. GSB1.
OC Bacteria; Chlorobiota; Chlorobiia; Chlorobiales; Chlorobiaceae;
OC Prosthecochloris.
OX NCBI_TaxID=281093 {ECO:0000313|EMBL:ASQ91190.1, ECO:0000313|Proteomes:UP000201322};
RN [1] {ECO:0000313|Proteomes:UP000201322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TY Vent \ GSB1 \ Ty-1 {ECO:0000313|Proteomes:UP000201322};
RA Bryant D.A., Liu Z., Li T., Zhao F., Garcia Costas A.M.;
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308,
CC ECO:0000256|RuleBase:RU003370};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751,
CC ECO:0000256|RuleBase:RU003370}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
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DR EMBL; CP022571; ASQ91190.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A222SKA8; -.
DR KEGG; pros:CHL67_09945; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; UER00717.
DR Proteomes; UP000201322; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR InterPro; IPR010953; Citrate_synthase_typ-I.
DR NCBIfam; TIGR01798; cit_synth_I; 1.
DR PANTHER; PTHR42871; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR42871:SF1; CITRATE SYNTHASE; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000201322};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532,
KW ECO:0000256|RuleBase:RU003370}.
FT ACT_SITE 311
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 367
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 447 AA; 50416 MW; D4F17F9CDE5A04B5 CRC64;
MADPEAKNTL TVTDNRTGKT YDIPVESGTI RTMDLRQIKV SEDDFGLLGY DPGYLNTASC
KSRVTYIDGD KGILRYRGYP IEQLAEQSTF LETAYLLIKG ELPDSERLAA WTHNIRHHTM
VHANLTKFMD GFRYDGHPMG ILVGTVGALS TFYPDAKNIF DEEMRKLQVR RLIGKMPTLA
AMSFRHSVGF PYVLPDNDLS YAGNFLSMMF KMTELKYRPD PILEKALDVL FILHADHEQN
CSASAVRSVG SSRVDPYSAL AAGCAALYGP LHGGANEAVI RMLERIGSVQ NVPGFIKSVK
EGEGRLMGFG HRVYKNYDPR AKIIKKIAFD VFEITGRNSL LDIALELEKI ALEDDYFVDR
KLYPNVDFYS GLIYQAMGFP LDMFPVLFAI GRTPGWLAQW TEHMLDEEQK IARPRQIYTG
AGKRDYQPIS ERTPNASDER KIGMCRL
//
