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Entry: A0A222VN95_9PSEU
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ID   A0A222VN95_9PSEU        Unreviewed;       369 AA.
AC   A0A222VN95;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   08-MAY-2019, entry version 9.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=DES30_101823 {ECO:0000313|EMBL:PWV84805.1},
GN   SAMN05421630_101513 {ECO:0000313|EMBL:SDC12705.1};
OS   Prauserella marina.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Prauserella.
OX   NCBI_TaxID=530584 {ECO:0000313|EMBL:SDC12705.1, ECO:0000313|Proteomes:UP000199494};
RN   [1] {ECO:0000313|EMBL:SDC12705.1, ECO:0000313|Proteomes:UP000199494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.5506 {ECO:0000313|EMBL:SDC12705.1,
RC   ECO:0000313|Proteomes:UP000199494};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PWV84805.1, ECO:0000313|Proteomes:UP000246674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45268 {ECO:0000313|EMBL:PWV84805.1,
RC   ECO:0000313|Proteomes:UP000246674};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
RT   the most valuable type-strain genomes for metagenomic binning,
RT   comparative biology and taxonomic classification.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; QGTN01000001; PWV84805.1; -; Genomic_DNA.
DR   EMBL; FMZE01000001; SDC12705.1; -; Genomic_DNA.
DR   KEGG; pmad:BAY61_10735; -.
DR   KO; K01626; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000199494; Unassembled WGS sequence.
DR   Proteomes; UP000246674; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199494,
KW   ECO:0000313|Proteomes:UP000246674};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199494};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       55    352       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   369 AA;  38836 MW;  EA395932EA10CB1C CRC64;
     MTLTAGLADV SDPVRELDNQ RTVDISPLLS PALLREEHPM TAAVAKTVAT GRASTVDILD
     GRDDRLLVVV GPCSVHDPAA ALDYAHRLAE HTAPLGDALH VVMRVYFEKP RTTLGWKGLI
     NDPDLDGSFA VNKGLRQARQ LLLDISALGL PVGCEFLDPI TPQFIADTVS WGSIGARTAA
     SQVHRQLCSA LSMPVGIKNS TEGDVQVAVD ATRAASAGHV FPGINADGLA ALITTAGNPH
     CHVILRGSAA GPNHDSATVA DTLGKLRAAG LPERVIIDAS HGNSGKDHVR QGEVVRELAR
     RTGSGEQGIT GVMIESFLAE GRQELTLGEA SELTYGQSIT DACLGWESTA ELLDELAAGV
     RTRRNQAGR
//
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