ID A0A222VWJ3_9PSEU Unreviewed; 292 AA.
AC A0A222VWJ3;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:PWV78525.1, ECO:0000313|EMBL:SDC87941.1};
GN ORFNames=DES30_104260 {ECO:0000313|EMBL:PWV78525.1},
GN SAMN05421630_104259 {ECO:0000313|EMBL:SDC87941.1};
OS Prauserella marina.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Prauserella.
OX NCBI_TaxID=530584 {ECO:0000313|EMBL:SDC87941.1, ECO:0000313|Proteomes:UP000199494};
RN [1] {ECO:0000313|EMBL:SDC87941.1, ECO:0000313|Proteomes:UP000199494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.5506 {ECO:0000313|EMBL:SDC87941.1,
RC ECO:0000313|Proteomes:UP000199494};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PWV78525.1, ECO:0000313|Proteomes:UP000246674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45268 {ECO:0000313|EMBL:PWV78525.1,
RC ECO:0000313|Proteomes:UP000246674};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; QGTN01000004; PWV78525.1; -; Genomic_DNA.
DR EMBL; FMZE01000004; SDC87941.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A222VWJ3; -.
DR STRING; 530584.SAMN05421630_104259; -.
DR KEGG; pmad:BAY61_28380; -.
DR OrthoDB; 9135493at2; -.
DR Proteomes; UP000199494; Unassembled WGS sequence.
DR Proteomes; UP000246674; Unassembled WGS sequence.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048666; RedAm-like_C.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR Pfam; PF21761; RedAm-like_C; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000199494}.
FT DOMAIN 7..160
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 165..288
FT /note="NADPH-dependent reductive aminase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21761"
SQ SEQUENCE 292 AA; 30498 MW; C0E379CB2A67C0F5 CRC64;
MTGQHPVTVI GLGSMGTALA EAFVDAGHPT TVWNRTAAKA APLVARGALH ARTMNKAITA
SPLVITCLTS YEDTIDAMGP AAAALEGRAL VALNSGSPAA ARNMAEWAHG HGARYLDGAV
KNVPSAVGAK DTLLYYGGDE SVFTEFESTL RVLGGDTVHL GAEVDLAALY EMAVGSTLLP
ALVGFFQGAA AMQARGLTAA SMVRYSAKWF EMISAILPGF AEEIDSGDYG KAASSVNLFH
SSIAQDEEFA KEANLDTAWH KPFHDLLERA VEAGHGNHSI SALTEVLKSR TA
//
