ID   A0A222YU41_9CAUD        Unreviewed;      1095 AA.
AC   A0A222YU41;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=SEA_MILDRED21_78 {ECO:0000313|EMBL:ASR75485.1};
OS   Streptomyces phage Mildred21.
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Stanwilliamsviridae; Boydwoodruffvirinae; Samistivirus;
OC   Samistivirus mildred21.
OX   NCBI_TaxID=2023959 {ECO:0000313|EMBL:ASR75485.1, ECO:0000313|Proteomes:UP000223009};
RN   [1] {ECO:0000313|EMBL:ASR75485.1, ECO:0000313|Proteomes:UP000223009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Chapman J., Chang C., Suresh T., Shishido T.C., Bindert I., Shaffer C.D.,
RA   Weston-Hafer K.A., Russell D.A., Pope W.H., Jacobs-Sera D., Hendrix R.W.,
RA   Hatfull G.F.;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MF155946; ASR75485.1; -; Genomic_DNA.
DR   Proteomes; UP000223009; Genome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          6..73
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1095 AA;  123626 MW;  F1A3D2EB93B92E0D CRC64;
     MTIQPVELHL HDHYSSMDGT NTAAEYMVRA KELGMTHLAQ TNHGTLGGHR EFQQAAMDAG
     IVPILGVEAY ISPTDRFDKR SKASRSDGTN AYNHLIILAQ DETGLQTLNR INRVAWTEGF
     YSKPRIDMEV LENDNEGLIV LSGCLNGLIC KAIEAGNLEE AMAIADRFKG ILGDRFFIEV
     QGHNPKSMNE ALFKIADEKG ILPVVTSDCH YARKEDLWIQ EAMLILSTNP KKNKDAELSK
     SQKMEMLERF NYLYPDRKMT FEKIEIYLHS AEEHRAAFKA QGFDREDIIT NTHVVADMVS
     NYPFHRGLDL LPRPKDGNPD DILEEKARQG LEDRGFASAP KYVERLEEEL EIIKSKDFST
     YFLIVEDMIS WAKSQGIMVG PGRGSGAGSL VNYALGITEV DPIVDNLLFF RFINPERNDF
     PDIDTDFEDA RRGEVKEYLR KKYGHVGSIA TYGYFKDKAV IKDAARVFCI PVGEVNRALK
     FVEKWEQFLT SPTTEEFRKK YPEVIKLAER LRGRIRQSGM HAAGVVIANQ PLANFAPIET
     AKDPNDANGP RIPLVAMDME QAADLGLVKL DALGLKALSI IKDTLRMIDE RHGRKIDLNT
     LPLTDSRVYA MLSEGYTKGV FQCEATAYTK LIIKMGGVKN FDELAASNAL VRPGAMNTIG
     AEYIARKNGK SPVKFHHFEM KPFTSETYGE ILYQEQVMLT MTELAGMKMA TADKVRKIIG
     KKKDAREFDQ YRAEFLEGAS KKVHPAVAEK LWHDFEAHAG YSFNKSHAIA YSRLSYYTAW
     LKKHYPLEFM CATLRNEGDK DALTEYLIEA KRMGIRMLLP HVNVSDVNFE IEGDAIRFGL
     ANIKFIREPG ALQLIEYRPF TSYSDLEAKV KEKGNGLSAR TLGGLNAIGA AAFEDHPRTG
     EERENYYEYL RIPAFELKFI PPKVRAQMTD LEDYKDNGAF CVLAMVKGIK RGDGWARLDL
     IDETGTAGVF TNPETPIEPG QMYAILVSDN RVARFATMDE LINRIPNGFV DYLYASEYGD
     IPDGMYKVLA FQRYITKAKK TMAYTTICDS EKNLYPVMAF PTMFHKAYGK CKDGAVIDAI
     LKQTQEGSWF YDNIL
//