ID A0A223ARE1_9FIRM Unreviewed; 441 AA.
AC A0A223ARE1;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=AXF17_03030 {ECO:0000313|EMBL:ASS37531.1};
OS Mogibacterium pumilum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales;
OC Eubacteriales Family XIII. Incertae Sedis; Mogibacterium.
OX NCBI_TaxID=86332 {ECO:0000313|EMBL:ASS37531.1, ECO:0000313|Proteomes:UP000214689};
RN [1] {ECO:0000313|Proteomes:UP000214689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700696 {ECO:0000313|Proteomes:UP000214689};
RA Holder M.E., Ajami N.J., Petrosino J.F.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP016199; ASS37531.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A223ARE1; -.
DR OrthoDB; 9762826at2; -.
DR Proteomes; UP000214689; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR PANTHER; PTHR45528; SENSOR HISTIDINE KINASE CPXA; 1.
DR PANTHER; PTHR45528:SF9; SENSOR HISTIDINE KINASE YRKQ; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ASS37531.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 166..218
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 240..441
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 441 AA; 49971 MW; 2DA3564B10B0F4B6 CRC64;
MRNLKIFPKL FVQTFAILGI LIIVVHLVVF LMFPKVYLEN RKSKINIRAN EVSAALQGKD
EQFVEQYLTF YSRSSEIKAF IDSNSDSGEV KIGENAENSI DKSSDNNSLI IETRNIKLAD
GSKLSVNFVS TADMRQEAKG LILKFLPLSL AVSLAISVLV SLIYARLLTR NVQEIKEVTT
RMMELDRSAL LPIESSDEIG QLKAQINDLY VALLELIDDL EVKNEEIIKL EKLKFDFFRG
ASHELKTPLA SLKIILENMK YNIGKYKNHD EYIGSCIDIV DNLSQNISQI LSVSSLEHLS
DEEELLNIKE ILSEILEKYS VMATQRGITI NNYLGEEQIY VGRTALKVVM SNVVSNAIKY
SDEAGCINIG ACDGWFYIEN SYENAEQLDC DKLFEVNFDL GKENSSGLGL YIVRNILLSY
GIEHKFERHE KSVAFMIKIK R
//
