ID A0A223CXM5_9BACL Unreviewed; 2314 AA.
AC A0A223CXM5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=CIG75_03350 {ECO:0000313|EMBL:ASS74119.1};
OS Tumebacillus algifaecis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC Tumebacillus.
OX NCBI_TaxID=1214604 {ECO:0000313|EMBL:ASS74119.1, ECO:0000313|Proteomes:UP000214688};
RN [1] {ECO:0000313|EMBL:ASS74119.1, ECO:0000313|Proteomes:UP000214688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=THMBR28 {ECO:0000313|EMBL:ASS74119.1,
RC ECO:0000313|Proteomes:UP000214688};
RX PubMed=25858243; DOI=10.1099/ijs.0.000240;
RA Wu Y.F., Zhang B., Xing P., Wu Q.L., Liu S.J.;
RT "Tumebacillus algifaecis sp. nov., isolated from decomposing algal scum.";
RL Int. J. Syst. Evol. Microbiol. 65:2194-2198(2015).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP022657; ASS74119.1; -; Genomic_DNA.
DR KEGG; tab:CIG75_03350; -.
DR OrthoDB; 9765680at2; -.
DR Proteomes; UP000214688; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 5.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000214688}.
FT DOMAIN 995..1070
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2051..2126
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2141..2178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2162..2178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2314 AA; 258279 MW; 0DC96BF5DBB750CD CRC64;
MADELTKQGE LLLEADGEEI EYYEFPASFA QNRMWLINQM NESSGMYNMP MAVRFEGPLH
IEALEKSLQE IVERHETLRT TFAMEDGELF QLIASQAKVK IPLLDLTSLS KAEQQAKVEA
LSSLEAETPF DLEEGPLLRS TLLKLGEQEH VLLFAKHHII SDGMSMAVMI HELVMLYEAF
IDGKPSPLPP LEIQYADFAA WQRDWFTGSV YEKHIDYWRG QLGGSIAPLQ LPTDRARPAV
ASPEGGHVLL PLPDSLMEQV NALTKQFKGS TLFMTMLAAY KAFLYRYTGQ DDLAVGTPIA
GRKQPGIEHL IGFFVNTLVL RTDLSDDPTF RELLERVRRV TLDAYTYQEM PFEKLVEELQ
PDRSVSNPFF QTMFVVQNVS TPDLTLRDLK ISAVEVQRNT AKFDLMFTVD QKDGKPILFA
EYSTDLFDYE TVERMMGHYL NLLQAVVDNP DLPISQLSML TEAEIHTLTV DCNQTERDFP
TDRLVHELFE QRAADNPDAI AIQYEEEQVT YRELNERANQ LARLLKGEGV GPEKVVGIYL
ERSPNMIVAL LAILKAGGAF VAFDPAFPQD RIGFMMEDSE VPVILTQQSL AGLLPQHEAK
TFCLDAQWDE VAGNGTDNLP NEATLQNLVY LIFTSGSTGR SKGVQVEHRN LLNYLYAIEE
VAQLGDGASY GNVSTLSADV GHTAIFPALC RGGTLHIIAQ ERLTDPDLMA EYFEKHPVDC
LKIVPTHLAA LMASQPLKVL PKHGAVVGGE TLRWDMIERV EQYRDDVWLI NHYGPTEVTI
AGVVYKVEKD PAMRQTVTVP LGRPLGNVQV YVLDKHLHPV PYGVAGEVYF GGAGITRGYI
KRPDLTAERY LKDPFKSDPD ARFYRTGDLA KRHPDGRLEF LTRADTQVKI RGYRVELGEV
ETVIGQHELV KENVVVARED VPGDRRLVAY IVKNEGVEGG TTDVRNYLKE ILPDYMIPAV
FVYLDAIPLT ANGKIDRRIL PDPEAELMEQ SEYIAPSTEL EAKVAQIWAE VLHVEQVSVV
DNFFDLGGHS LMVTQVVSRV NKEFAIKIPL RTLFEAPTVV DLALRVEAQM QETLAPTASE
APIKPVARDT KLPLSFSQQR LWVLEQLIPG LTAYNIPYAV RLTGALHNEH FERALNMMIE
RHESFRTTFS DASGEPEQLI HEAVWTPLQL VDLQHLSGTE QEAEVARLVR AENDTPFDLR
KGPLIRNQLL KLGEQEHVLL LTLHHIISDG WSRGILTKEL THLYDVLVTG KESALSPLPL
QYADFAVWQR EFLEQELGSQ LSYWKEKLGQ DLPVLQLPTD RPRPPMQTHN GAQLTFRLPQ
KVGDQLTALS QKQGATLFMT LLAAFQTLIL HYSGQEDFAV GTPIANRNRQ DTESIIGFFV
NTLALRADLS GNPTFLELIG RAKDAALGAY ANQDVPFEKI VEELETDRDL SRSPVFQVVF
GLQNFEQSKI ELAGLTFEPV ADTGTTSKFD LSLLMSEHED QSIGGTFEYN SDLFEASTIE
RMLHQFVQLT AALVENPAQR VGELSLLTTA EREQLVVEWN RTASAYPGAS LQELFEAQAA
AIPDAVAVVS GNDSLTYRQL NERANQIAHH LKALGVGPDA LVGLCIERSL EMVTALLAII
KAGGGYVPID SDYPQERIAF MLEDTNVSVL VTQSALAEKL PLPDSHVICL DRDMQLFADQ
STDNPNCATT QDNLAYVIYT SGSTGRPKGV LVPQRGVVRL VKNTNYMQMT ADQVFLQTAS
LSFDAATFEI WGPLLNGAKL ALMPVGQSSL EDLGRLVKTY GVTVLWLSAG LFHQMVEFRL
DDLQGVKYLL SGGDVLSVAH VKKALDNLSG LTIINCYGPT ENTSFTTVHA MTDVAQVGNT
VSIGGPISNT TVYVLNQHLQ PVPVGVPGEL LTGGDGLAVG YLNRPDLTQE KFVETAFGRL
YKTGDLVRWL SDGTLEFMGR IDQQVKIRGF RIEIGEIETL LSNLPGVRAC TVIAHEADGD
KRLVGYVVPE PGEQVQVEEL RTLLRKQLPD YMMPSFLVLL DELPLTSNGK VDRKRLPSPE
GTLSDRDDYV APRTEEEQKV AQIFANVLRV EKVGMHDNFF ALGGHSLLAT QVVSRIAEEY
GVAVPLRLLF QFPTVAEFTA ELLRARAEGT VQTTGAMEIQ RVSRRSEVPE ISAVPRRRGG
SPRSADAQRA EEPKHTGEPY VHPLREAVRL DLMERAQYEL FAAHDVLRTL LHGTEDELVK
QVKDAKWSPL HVIYLRDLEE QALEAKLQEL LQTERQKPLE PQSETVRFYL IQKGASDFVF
VLNLHPLLAK EVSAAELVKE LLTKYQSYLQ ELAQ
//