ID A0A223D1J7_9BACL Unreviewed; 5590 AA.
AC A0A223D1J7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=CIG75_09800 {ECO:0000313|EMBL:ASS75247.1};
OS Tumebacillus algifaecis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC Tumebacillus.
OX NCBI_TaxID=1214604 {ECO:0000313|EMBL:ASS75247.1, ECO:0000313|Proteomes:UP000214688};
RN [1] {ECO:0000313|EMBL:ASS75247.1, ECO:0000313|Proteomes:UP000214688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=THMBR28 {ECO:0000313|EMBL:ASS75247.1,
RC ECO:0000313|Proteomes:UP000214688};
RX PubMed=25858243; DOI=10.1099/ijs.0.000240;
RA Wu Y.F., Zhang B., Xing P., Wu Q.L., Liu S.J.;
RT "Tumebacillus algifaecis sp. nov., isolated from decomposing algal scum.";
RL Int. J. Syst. Evol. Microbiol. 65:2194-2198(2015).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP022657; ASS75247.1; -; Genomic_DNA.
DR KEGG; tab:CIG75_09800; -.
DR OrthoDB; 9765680at2; -.
DR Proteomes; UP000214688; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 3.
DR CDD; cd12116; A_NRPS_Ta1_like; 1.
DR CDD; cd19531; LCL_NRPS-like; 5.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 3.40.50.980; -; 10.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF13193; AMP-binding_C; 5.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 5.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 5.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000214688}.
FT DOMAIN 989..1064
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2053..2128
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3119..3194
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4172..4247
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5236..5311
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 5590 AA; 622950 MW; 8BB825669BB548E8 CRC64;
MTFTSQEETA NTTEVYVFPA SFAQQRMWVL DQLMPGTSVY NIPFAVRMQG EVDGDVVEAC
LNEIVARHEV LRTRFLPIDG QPMQVISPSL TLAMLRADLR GAEEGEREAA LRHLVETEAA
QPFDLRKGPL LRVQLICVQE GEHVLLLTMH HIISDGWSMG VFINEFVALY EAFRAGLPSP
LPDLEIQYAD YAEWQRDYLQ GEVLEQQLAF WRQQLGDDPP ALQLPTDFPR PPVQTNRGTT
MSFTLPTELA ERLKVVCQEQ GVTLFMLLIT AFHTLMYRYS GQEDISVGTP VAGRNSQETE
ELIGLFVNTL VLRADLSGNP AFADLLQRVR ETAVDAFASA DVPFEKLVEE LKPERDLSIS
PLFQAMFTLQ TTTPSGIELP GVTISPFEFE SRIAKFDLEL AMQDRPEGLT GWLEYNTDLF
TPARISRMLN HFQTLLEGVA ANPAQPIGEL PLLTEAERHQ LLIEWNDTSA EFPQDICLHH
LFEQQVDQTP DLVAAVYGEQ ELTYGELEDR ANQLAHHLQS LGVGPDVPVG VCVERSLDLV
IALLGVLKAG GAFVPVDPEA PLDRIDQLLE ESQAAVCLAQ AHLKGGLPTQ RTRFVFLDEE
RAEIAAYPKF RPSAHVLPHH LVSIYYTSGS TGKPKGVANE HLGWVNRMIW NQKAHNLQAG
ETVLQKTTLT FDDSAVEFFW PLMVGGRIAL LEPGLHRDPR AILAAAERFE AVLIQFVPSV
LRLFLEEVTP AAEAKLCALR SVISSGEALR PELVDLFFER LPGRKLYNLC GATEVSIDST
VHLCTEDDLQ GEIVSIGKPF DNNTLYILDA HQQPVPIGAV GEIYYGGVGL ARGYWMRPDL
TEKAFLDNPF EPGTRMYKTG DRAYFRPDGS VQFLGRNDDQ VKIRGVRVEL GEIEVALALH
PSVRDNVVIA HEFVKGDKRL IAYVLAHPGQ AADVAEYRRF MKEKLPDYMV PSLFMLVDHI
PLTPNGKVDR RALPLPSAEL LGREAEYRAP RNSVEQRLTE LYSEVLGVPK VGISDNFFEL
GGHSLLATQV VSRIRDAFQI EFQLRHLFEA PLISDLASRI EASLFEQNGD RLPPIRAGSR
DGNLPLSFAQ QRLWVIDRML PESSVYNIVF GLRMTGELDL SALERSLTEI VSRHEILRTT
FTEAEGVPVQ VIAEARSQTL DVIDLTLLDS EAREQEVLRQ AQSEAQRGFD LTRGPLFRCF
LLRLATDEHV LVLNMHHIIS DGWSTGVLVG EFASLYAAFT KAEPSPLAEL AVQYADYAQW
QRDWLAGEVL DAQLAYWKEK LRGVETLQLP TDSPRPAVQS NRGGRIPIQL PQEVVQGLSE
LSQTEGATLY ITLLAAFQTL LYRYTGQEDF AIGSPIAGRT AAEIEPLIGF FVNTLVLRSD
LSKELTFREL LERTRVTTLE AFAHQDVPFE KLVEELQPER SLSHSPLFQV MFTLQNTPIS
QLELPGLSVA PLEIEHGNAM FDLSLTLAET ETGVQGELEY NCDLFAEQTV ARMVEHFTVL
LSAIIHMPDQ KLSSYPLLHE TEREQVLEGW NGRAIEVPAG MCVHQLFEQQ AEQKPDATAI
VFAGNRWTYL EVNEQANRLA HHLRRRGVGR ETLVGICVER SEQMVITVLA VLKAGGAYVP
IDPSYPKERI SLMLEQCDLT LLLTESELLG MLPNHQVPVI CVDRERELLA QEPVHNLVGE
ATPTDLAYVI FTSGTTGVPK GVMVQHDTLV YVAHCYLQEH RLDHFDARML QIASMSFDVF
AGDLLRLFVS GGSLVICPAD VRLDVAALYE LIKAEAINYI DLTPGLAVPL LEYVYQNGFK
IDQVELFSVG SDVFSAADYR RMLERFGNGM RIINSYGITE TTIDSAYFEI DLAQFDLSLA
GSVPIGGPLP GTCFYILDAE MNPQPVGVPG ELYIGGRGVA RGYYKRPDLT EERFVHNPFR
TGERMYKTGD LGAWRPDGTV NFLGRADNQV KVRGFRIETG EIEAVLSQHS QVREVAVIVR
EDVPGDQRLA AYYTALGALE AEELRRLAKA ELPTHMVPAA FVQLEAMPLT PNMKLDRKAL
PVPVYLGTGE YVAPSTALEQ MIADSFAEVL QAERIGAEDD FFASGGHSLL ATQVVSRLNA
RLQLEVPLRL LFEYPTPFEL AKGIEHLQTE ARTEELPPLR LVSRDEALPL SFAQQRLWML
DQMLDDRSVY SVPLAVRLTG RLDATALEQS FADLIERHEV LRTRFAEDKG HPVQIIDHEQ
SVPLEFADFQ DVPQEEREAL VRRQIGEEVR RPFELSRGPL LRTLLMRIAP DEHVLLLNMH
HIITDGWSME ILIRDLSALY ESRAKGEPAT LTEQPLQYAD FALWQREWLT EDVLESQMNY
WRKQLGGEPP VLQLLTDRPR PAVQTYRGAT IEFQVATETA QRLRSLSRQH GTTLFMTLLA
AFQTLLFRYT GQEDFCVGTP IAGRRKQETE QMIGFFVNML VLRSDLSGND SFETVLARVR
ETALNAYAHQ DVPFERLVEE LHNGRDLSSS PLFQAVFALQ NDAKTQVELT DLSLSIFELP
QEVARFDLNM TLSEAGDALF GGLEYNTDLF DASTIERMIG HFQNLLHSIV QEPQVELSRL
PMIEEVERTA LLYECNKTQV DYPTERLVHE LFEEQAALVP QRLAVVYEDQ HLTYQQLNEC
ANQLAHQLRE WGVGPDTIVG ICLERSPMMI VALLAVLKAG GAYVAFDPTY PQDRVAYMLE
LTQVPVVLTQ TSLLAVFSKS DVLSLCLDRD WAQVADNSTE NLVSGATANH LVYVIFTSGS
TGRPKGVMVE HRNVLNYLYG IGDVMQLPAE ASYGNVSTLA ADVGNTAIYP ALCRGGTLHL
LSQERISDPG LMADYFAEHP IDLLKIVPTH LAALMTAAPE KVLPQKGMVL GGETLRWDLI
KRIEEHGSGQ FVINHYGPTE VTIAGVVYRV EADLSSRQTP TVPLGRPIGN VQVYLLDEHL
SPVPFGVPGE VYFGGAGVTR GYLGRPDLTA ERYLPDPFRT EPGARLYKTG DLARRLPDGR
LEFLTRIDSQ VKIRGFRVEL GEVETVLGNH PQVQENVVVA HEDETGDRRL IAYVVLAEGA
EGEQVDLRQF MQAELPDYMV PSAFVEMSAI PLTANGKIDR RALPVPDLNL RLEDADYIAP
RTSTEQTLAD IFAEVLRLDK VGIEEDFFGL GGHSLLATQA ISRISAAFAI KVPLRSLFEC
PTVASLAQKV QQLQAESRSS LDTPITRASR TQDLPLSFAQ ERMWLLDQLM PASAAYNMPY
AVRLSGNLNV SALQQSVNEL LVRHESFRTT FQEREGGTVQ VIAEPAWRKL LVEDLRVIPQ
QQRERALLQE VQTEADQPFD LRSGPLVRFR LWQTADDEHV LLLTLHHIIS DGWSRGIFTQ
ELGELYDHLV RGEQSMLPEL PLQYADFAVW QRSWLQGPEL QNQLAYWKNQ LSGDLPVLQL
PIDQPRPAVQ TYAGATAHFA LTPALTEGLQ QLSQQQGATL FMTLLGAFQT LLGRLAGQND
ILVGTPIAGR TRKDTERIVG LFINTLVMRT DLSGEPNFVQ LIDRVRDMTL EAFAHQDLPF
EKLVDELELE RDMSRSPLFQ TFFALQNMPT ATDFALQDVR MSAFEFEHTT AKFDLSLYMT
VEEETLTGVF EYNTDLFEAA TIERLLGHFH TLLDAIVHDP TQPISQLPLL NDAERSQLLH
DWNSTERDVP SHLPVHRLFE AQVQQTPLAR AIVCNGESLT YEELNERANR LAHLLRERGA
GPDQLIGICL ERSLDLLIGV LGILKAGSAY VPLDPTYPQE RLHLMLEDSQ ASLLVTKSAL
ATSLPPHGAQ VIDLEDGEPL TAFPAENLQV SVAEHDLAYV IYTSGSTGTP KGVAIEHRSL
SNFLLAMQHE LEFTAQDVLC AVTSLSFDIA GLELYLPLIC GAQIVLADRA TVGDGERLAR
LLDEKQVTVL QATPVTWQML LAVGWTNSSR LRMLVGGEAL SAELAANLLD LQAPLYNLYG
PTEATIWATV HRVEEVKRPM PIGRPIANTR AYVLDQKLQP VPVGVSGELY LGGHGIARGY
LNRPDLTAER FLPSPFDGED TLYKTGDAVR WLACGTLEYL DRLDNQVKIR GFRIETGDIE
AALSLHPHIN QALVTARADK TGNKRLVAYL IAPQLQGVED LSLFVQSKLP SYMLPDAFLV
LEQFPLTPNG KIDRNALPEP SASIDKTQMH VLPRTPLEEQ IVSIWAEVLG HEEIGVTDNF
FRLGGHSLRA VQMISRLNAR LQKRVPLRTL FEAPTVAGLA EAILHLQPEA DGQTIPVIAD
GQALPLSFAQ QRLWLLEQML SSNSLYNMPF AVRLTGQLDR RAFENSLLLL VQRHESLRTS
FQESEAGVVQ VIAPASAGPL LDFHDLRELA SAKREQTAHE LVQRATDMPF DLQTGPLVRF
QLLQVEVEEH LFVVTMHHII SDGWSLSIFA EELSALYVAH LQGGEGESLL QQLPQVPVRY
ADFAAWQRQW LQGVEMERQL SYWKRQLGSE LPVLQLPTDR PHPPVQTHNG AVEMFAIDAG
LTAKLQQLSN EQDVTLFMTL LAAYQTLLMR YSGQEDIAVG TPVAGRQSEA TERIIGFFIN
TLVMRTDLSG APSFLDLLTR VRETALGAFA HQDVPFEQLV EMLATDRDAS RTPLFQVMFA
LQNVPEQPLQ LQGLAIDELS LVRNTAKFEL SLALEEVDGQ LNGAFEYNTD LFDATTISRM
IGHFRNLLES IVDAPQKALG DLTLLSAAER SQLLGTWNET QGEYPEQVCI QQLFEQQALR
TPHALAVVAD KISLTYEELN GKANSLAHYL RKKGAGRESV IALCTERSAQ MIIGMLGILK
AGAAYLPLDI THPAERLQLM LTDAHPHLLL TEAHLQPLLQ GAGAETILLD AHEAQFAQES
MDNPSSVNRP DDLFYILYTS GTTGVPKGVE CIQRGPINLI ADLQHKRAVR TGDNCSVWTS
VGFDVSVLEI FSALLHGATV QIVPETVRTD SDAFFRWLWQ NEIHSAYLPP FLLKEFANWL
ASGNSTSLRR MIVGVEPIRE RLLEQLHRQI PGVTIINGYG PTEASIASDL YVFDPQQVKD
RVTPIGRPVQ NTSTYIFDRH LNPVPIGVYG EIYLGGIGLA RGYRNQPELT AEKFIPHPLK
PDSGEVLYKT GDMARYLPDG NIEFLGRADQ QVKIRGFRVE LGEVEAALTK LPTVAESICL
VHADEQGQKR LIAYILPASQ VGASELRSSL QAVLPGPMVP SAFVMVERWP LSPNGKIDRR
ALPKPEWNRA GVQYVPPRDE LEWQLATVWQ DVLGQARVGI EDDFFTIGGH SLLAVRLLAE
VEKRLGMRLQ MASLFQHPTV EQLAELVRQG TSEAVIEHSP LVKLNAGTAG MTPLILVHAV
SGNAFSYLEL SAELRERPIF ALQAQGLEPG SAPLTDVQTM AARYIESVRA VQPQGPYLLA
GWSFGGAVAY EMAAQLVRLG ERVERVLLLD TRMPTAVGET VAELDEAELA LGFVQDLAGR
FALADEVEVE AGQNERLSAT DILRRALQVA RAHRVLSDSF ELHDLERMFH VYRANITALC
RYQPQPADVP LVLLRAEQGS LPATALSEWQ GLGCEAVSYD VPGNHYTVVQ QPHVKTLAAT
MRAVLTERSR
//
