ID A0A223NY73_9SPHI Unreviewed; 797 AA.
AC A0A223NY73;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=MuYL_2916 {ECO:0000313|EMBL:ASU34803.1};
OS Mucilaginibacter xinganensis.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Mucilaginibacter.
OX NCBI_TaxID=1234841 {ECO:0000313|EMBL:ASU34803.1, ECO:0000313|Proteomes:UP000215002};
RN [1] {ECO:0000313|EMBL:ASU34803.1, ECO:0000313|Proteomes:UP000215002}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BJC16-A31 {ECO:0000313|EMBL:ASU34803.1,
RC ECO:0000313|Proteomes:UP000215002};
RG Henan University of Science and Technology;
RA You X.;
RT "Complete genome sequence of Mucilaginibacter sp. strain BJC16-A31.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; CP022743; ASU34803.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A223NY73; -.
DR KEGG; muc:MuYL_2916; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000215002; Chromosome.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000215002}.
FT DOMAIN 69..228
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 311..577
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 704..792
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 797 AA; 89885 MW; 208AC02FFE4B61E7 CRC64;
MRLGSNRISF LIKKPKVIII LSFLSALFLL FWLCLPSPLF NSPTSYVIDD TDGQLLGASI
ATDGQWRFPP NADVPEKFRQ CIITFEDKRF MHHPGFDLLA LGRAFRQNFQ SNKVTSGGST
ITMQVIRLAT KHKRNIWNKV IEIFMAMRLE AGFTKNEILS FYASNAPFGS NVIGLDAASW
RYFGRSPDKL SWGEMAAMAV LPNSPSLVHP GKNRATLLKK RNLLLDRLYR NGIIDSTTAA
LAKFEPVPDR PMPLPQLAPH LLQRFKTDHQ INTNGDTRIK TSIRAALQQQ VNDILERHHQ
VLKANDVNNI AAIVLDVETG ATLAYAGNIA HKEDPEMESD VDVINAPRSP GSTLKPVLYA
SMLHDGLLLP NSLMPDIPTQ IAGYHPENFD LGYDGAVPAS KALSRSLNVP AVKMLQQFKY
ERFYDVLQKM GVTTLKRPAD HYGLSLILGG GENTLWELTG IYADMARVLN HYQKYNGKYN
PADYHNPVYK INTETKQPDL EKSGLLDAGS IFYTLQAMEE VMRPGEEMLW QQFSSSQRIA
WKTGTSFGFR DGWAIGITPK YVVGVWVGNT DGEGRPNLTG ISTAAPALFE IFRLLPVTRD
WFEMPVGEMV KIKVCHQSGY RAGEYCDDQD EMWVPKSGLK VAVCPYHQLV HLSWDEKWQV
TGNCTPPNQI VNKHWFVLPP SMEYYYKTKN YQYRVLPPFR PDCVQAENSA PMEVIYPKDG
AKIYIPLEAD GSRGRVIFNA AHRQKGVKIF WHLDNKYVGE TTDFHQMAVN PPPGKHVLTL
VDENGNTVHI EFEILQK
//
