ID A0A223V9M1_9FLAO Unreviewed; 310 AA.
AC A0A223V9M1;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=CD-NTase-associated protein 12 {ECO:0000256|ARBA:ARBA00034339};
DE EC=3.2.2.5 {ECO:0000256|ARBA:ARBA00034327};
DE AltName: Full=NAD(+) hydrolase {ECO:0000256|ARBA:ARBA00034355};
DE AltName: Full=TIR-STING {ECO:0000256|ARBA:ARBA00034366};
GN ORFNames=CJ263_16400 {ECO:0000313|EMBL:ASV31668.1}, GCM10011412_34980
GN {ECO:0000313|EMBL:GGD93967.1};
OS Maribacter cobaltidurans.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Maribacter.
OX NCBI_TaxID=1178778 {ECO:0000313|EMBL:ASV31668.1, ECO:0000313|Proteomes:UP000215244};
RN [1] {ECO:0000313|EMBL:ASV31668.1, ECO:0000313|Proteomes:UP000215244}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B1 {ECO:0000313|EMBL:ASV31668.1,
RC ECO:0000313|Proteomes:UP000215244};
RA Wu Y.-H., Cheng H., Xu X.-W.;
RT "The complete genome sequence of Maribacter sp. B1, isolated from deep-sea
RT sediment.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GGD93967.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.15508 {ECO:0000313|EMBL:GGD93967.1};
RX PubMed=30832757;
RA Wu L., Ma J.;
RT "The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing
RT project: providing services to taxonomists for standard genome sequencing
RT and annotation.";
RL Int. J. Syst. Evol. Microbiol. 69:895-898(2019).
RN [3] {ECO:0000313|EMBL:GGD93967.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.15508 {ECO:0000313|EMBL:GGD93967.1};
RA Sun Q., Zhou Y.;
RL Submitted (DEC-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.5;
CC Evidence={ECO:0000256|ARBA:ARBA00034248};
CC -!- SIMILARITY: In the C-terminal section; belongs to the bacterial STING
CC family. {ECO:0000256|ARBA:ARBA00034315}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP022957; ASV31668.1; -; Genomic_DNA.
DR EMBL; BMJL01000010; GGD93967.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A223V9M1; -.
DR KEGG; marb:CJ263_16400; -.
DR OrthoDB; 5497289at2; -.
DR Proteomes; UP000215244; Chromosome.
DR Proteomes; UP000603042; Unassembled WGS sequence.
DR GO; GO:0061810; F:NAD glycohydrolase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd22659; STING_bact-like; 1.
DR InterPro; IPR019302; CAP12/PCTIR_TIR_dom.
DR InterPro; IPR046876; Prok_STING.
DR Pfam; PF10137; CAP12-PCTIR_TIR; 1.
DR Pfam; PF20300; prok_STING; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000215244}.
FT DOMAIN 6..124
FT /note="CD-NTase-associated protein 12/Pycsar effector
FT protein TIR"
FT /evidence="ECO:0000259|Pfam:PF10137"
FT DOMAIN 155..291
FT /note="Prokaryotic STING"
FT /evidence="ECO:0000259|Pfam:PF20300"
SQ SEQUENCE 310 AA; 35624 MW; 1FD5CCBE12163949 CRC64;
MIIRPKIFIG SSSAGLEIAE KVKAHLSNIA DCFVWSEPDI WETNRSTFDN LIRMANYFDF
GVFVATADDL TETNDRLVIE PRDNVILEMA LFLGAMGHHK SFLLVEKGIK LPTDFNGIYM
PRFDTNDEDS IKDACDTYMA KIEEHYQLGH LSLYPTTALA IGYYKNFIAD LVESVQTAKK
MTIDETEYTD FKLKVVIPAD LKGMIREKAQ VFYKRNGFSA NAMEAKFRKH HLWFQLDKKN
APIAIMYDMP STLTGIDDAI ELILQKSYKG RTKIQELIEQ KELNNFRRVL QMQIDSSPFA
QEVVEIIDEF
//
