ID   A0A224WZH2_9LACT        Unreviewed;       446 AA.
AC   A0A224WZH2;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Permease IIC component {ECO:0000256|PIRNR:PIRNR006351};
GN   ORFNames=RsY01_1047 {ECO:0000313|EMBL:GAX47447.1};
OS   Lactococcus reticulitermitis.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=2025039 {ECO:0000313|EMBL:GAX47447.1, ECO:0000313|Proteomes:UP000218689};
RN   [1] {ECO:0000313|Proteomes:UP000218689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rs-Y01 {ECO:0000313|Proteomes:UP000218689};
RA   Ohkuma M., Yuki M.;
RT   "Draft genome sequence of Lactococcus sp. strain Rs-Y01, isolated from the
RT   gut of the lower termite Reticulitermes speratus.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC       system (PTS), a major carbohydrate active -transport system, catalyzes
CC       the phosphorylation of incoming sugar substrates concomitant with their
CC       translocation across the cell membrane.
CC       {ECO:0000256|PIRNR:PIRNR006351}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAX47447.1}.
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DR   EMBL; BEDT01000002; GAX47447.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A224WZH2; -.
DR   OrthoDB; 1550290at2; -.
DR   Proteomes; UP000218689; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR   InterPro; IPR003352; PTS_EIIC.
DR   InterPro; IPR004501; PTS_EIIC_3.
DR   InterPro; IPR004796; PTS_IIC_cello.
DR   NCBIfam; TIGR00410; lacE; 1.
DR   PANTHER; PTHR33989; -; 1.
DR   PANTHER; PTHR33989:SF4; PTS SYSTEM N,N'-DIACETYLCHITOBIOSE-SPECIFIC EIIC COMPONENT; 1.
DR   Pfam; PF02378; PTS_EIIC; 1.
DR   PIRSF; PIRSF006351; PTS_EIIC-Cellobiose; 1.
DR   PROSITE; PS51105; PTS_EIIC_TYPE_3; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR006351};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR006351};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218689};
KW   Sugar transport {ECO:0000256|ARBA:ARBA00022597,
KW   ECO:0000256|PIRNR:PIRNR006351};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR006351}.
FT   TRANSMEM        21..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        69..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        105..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        160..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        347..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        376..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        414..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          5..431
FT                   /note="PTS EIIC type-3"
FT                   /evidence="ECO:0000259|PROSITE:PS51105"
SQ   SEQUENCE   446 AA;  48178 MW;  F60AC47B7239FCC9 CRC64;
     MFAKFINKLE YIGGKVSTFT YVSVIRVAFV KLMPIIILGS FATLLNNVLC SATNGLPALF
     PNLMFLTDFS PIFSAINYAT MNFLSIFVVF LVAQAMGKER KIDETFAGIV GLICYISLVP
     TAITRVFDVA TESYKLTGKA VGELVIPNAL AVNYTNTRGM FLAMIVGIIA TEFLAKLLNG
     GKMNIHMPDS VPPNVATAFE VLFPSITVAG VFGIFGFAFQ KVTEMNISDV IYKVLQIPLE
     AIMQHPAGVI VLALLCQVFW LIGIHGAQVI GIVKDPIGLA AIAINLEAHE AGKALPNIFT
     YTFWNIYATI GGSGCTIGLL IAIFFFSKRA DYRTIGGFSA IPALFNINEP LIFGLPLVLN
     PIIAIPFIFA PVISSIIGYF LTYVGFAASA FITVPFTLPP LVNAFVSTGS FKTVIVQLIC
     IVVTVLIYAP FVIAANQQAH EESFSL
//