ID   A0A224X8K3_9LACT        Unreviewed;       479 AA.
AC   A0A224X8K3;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Guanine permease {ECO:0008006|Google:ProtNLM};
GN   ORFNames=RsY01_143 {ECO:0000313|EMBL:GAX46564.1};
OS   Lactococcus reticulitermitis.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=2025039 {ECO:0000313|EMBL:GAX46564.1, ECO:0000313|Proteomes:UP000218689};
RN   [1] {ECO:0000313|Proteomes:UP000218689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rs-Y01 {ECO:0000313|Proteomes:UP000218689};
RA   Ohkuma M., Yuki M.;
RT   "Draft genome sequence of Lactococcus sp. strain Rs-Y01, isolated from the
RT   gut of the lower termite Reticulitermes speratus.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR005353};
CC       Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR005353}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697,
CC       ECO:0000256|PIRNR:PIRNR005353}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAX46564.1}.
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DR   EMBL; BEDT01000001; GAX46564.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A224X8K3; -.
DR   OrthoDB; 9808458at2; -.
DR   Proteomes; UP000218689; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR   InterPro; IPR045018; Azg-like.
DR   InterPro; IPR026033; Azg-like_bact_archaea.
DR   InterPro; IPR006043; NCS2.
DR   PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR   PANTHER; PTHR43337:SF1; XANTHINE_URACIL PERMEASE C887.17-RELATED; 1.
DR   Pfam; PF00860; Xan_ur_permease; 2.
DR   PIRSF; PIRSF005353; PbuG; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR005353};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005353};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218689};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|PIRNR:PIRNR005353};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|PIRNR:PIRNR005353};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005353}.
FT   TRANSMEM        18..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        46..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        75..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        130..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        216..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        390..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        419..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        460..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   479 AA;  50219 MW;  E05AB5C522FCB5BF CRC64;
     MDKFFKLTES GTTVSREIMA GLTTFFAMSY ILFVNPDMLS KTGMPYQAVF LATIIASVIG
     TLIMGLFANV PYAQAPGMGL NAFFTFTVVF GLGYSWQEAL AMVFICGIIN ILITVTKIRK
     MIIKAIPESI QHAIGGGIGI FIAYIGIKNA GLLKFTLDPG TYTVLGKGAD KGTATIEGAA
     SAVPALVNFT QPAVLVALVG IVITAILVVK NVKGAILISI VATTIIAIFA GVVDLSAIDF
     KGNSLGSAFK ELGQTFGAAF SQKGMGSLFT DSAKIPQVLM TILAFSLSDT FDTIGTFIGT
     GRRSGIFSAE DEKSLEEGSG FSSKMDKALF ADATATSIGA IFGTSNTTTY VESAAGIGAG
     GRTGLTSVVT AICFLLSSVL LPFISIVPSA ATAPVLIIVG VMMLGSFKDI NWTDLEEAIP
     AFFASIFMGF AYSISYGIAA GFIFFAITKV VTGKAKEVSP IIWVVNFLFI LNFIILAVI
//