ID A0A225ADR3_9EURO Unreviewed; 1511 AA.
AC A0A225ADR3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 08-NOV-2023, entry version 22.
DE SubName: Full=ABC transporter CDR4 {ECO:0000313|EMBL:OKL58610.1};
GN ORFNames=UA08_06012 {ECO:0000313|EMBL:OKL58610.1};
OS Talaromyces atroroseus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Trachyspermi.
OX NCBI_TaxID=1441469 {ECO:0000313|EMBL:OKL58610.1, ECO:0000313|Proteomes:UP000214365};
RN [1] {ECO:0000313|EMBL:OKL58610.1, ECO:0000313|Proteomes:UP000214365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 11181 {ECO:0000313|EMBL:OKL58610.1,
RC ECO:0000313|Proteomes:UP000214365};
RA Rasmussen K.B., Rasmussen S., Petersen B., Sicheritz-Ponten T.,
RA Mortensen U.H., Thrane U.;
RT "Talaromyces atroroseus IBT 11181 draft genome.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000256|ARBA:ARBA00006012}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKL58610.1}.
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DR EMBL; LFMY01000009; OKL58610.1; -; Genomic_DNA.
DR RefSeq; XP_020118731.1; XM_020268688.1.
DR STRING; 1441469.A0A225ADR3; -.
DR GeneID; 31005768; -.
DR OrthoDB; 5473955at2759; -.
DR Proteomes; UP000214365; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR005285; Drug-R_PDR/CDR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR NCBIfam; TIGR00956; 3a01205; 1.
DR PANTHER; PTHR19241:SF498; ABC TRANSPORTER PROTEIN; 1.
DR PANTHER; PTHR19241; ATP-BINDING CASSETTE TRANSPORTER; 1.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000214365};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 519..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 764..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1156..1173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1185..1207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1219..1241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1261..1286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1306..1329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1341..1365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1458..1479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 157..406
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 848..1091
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 29..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 69..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1491..1511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1511 AA; 169067 MW; 485407BC6B0FEB31 CRC64;
MSQIPAPGGA GAIAAAQDLA HRVELSISEK TTSFEDSSND STKQGSFEDL KQHERDEITD
LARQISRISN RSNTYSGEPT NSFLNPDADP ELDPNSESFK QKKWVKNLLH ITSRDPEKYP
RRTAGVTFRN LIAYGYGTAA DYQGDVFNTW LKAFGYIRGL LGLRKKKRID ILRDFEGLVK
SGEMLLVLGR PGSGCSTLLR TLCGETHGLW LDEGTDIQYE GVSYEEIHSR FRGEVIYQGE
QDIHFPQMTA GDTLLFAARA RTPANRLPGV TRDQYATHMR DVVMAMFGLS HTKNTKVGNE
YIRGVSGGER KRVSIAETTL CGSPLQCWDN STRGLDSATA LEFVRTLRTS TRYTGSTAIV
AIYQAGQAIY DIFDKTIVLY EGREIYFGRA DDAKRFFVDM GFYCPPRQTT ADFLTSLTSP
AEREVRPGFE GRVPNTPDEF VARWRESTER QALIAEIEAS QAEHPLGGDK YTKFTESRKM
EKAKGTRASS PYTLTYLMQI KLCFWRGVKR LQGDMSNTLA GVIGNIVMSL IVSSMFYNLP
EDTDSFYQRS SLMFFAILLN AFASILEIQT LWSQRPVVEK HKKYALYHSS AEGLSSIFVD
LPAKVATAIA FNLILYFMTG LRRTPGAFFT FFLFSFTTTL VMSNIFRFIG SLSRTQAQAM
VPAGIFMLAL MIYTGFTIPI RDMHPWFRWI NYINPIAYAF ESLMVNEFSD REWRCSTFVP
SGPGYNNLPG QSFICSATGS VTGDTTVNGN DYLALTYQYS RSHLWRNFGI LLGFFFFFLG
LVIIATEHVT AKPSKGEILV FPRGKIPAFT KEKGGNEDPE AYSKNVQTGV EDSGVDETAA
IVRQTSIFHW QDVCYDIKIK GEPRRILDNV DGWVKPGTLT ALMGVSGAGK TSLLDVLANR
VTVGVVTGQM LVDGHLRDSS FQRKTGYVQQ QDLHLETSTV REALRFSALL RQPQSVSKEE
KYAYVEEVIK MLGMNEYAEA VVGVLGEGLN VEQRKRLTIG VEIAAKPELL LFFDEPTSGL
DSQTAWSICQ LMRKLANHGQ AILCTIHQPS AILMQEFDRL LFLAKGGRTI YFGDLGTNMG
ELISYFERNG SPKCPESANP AEWMLEVIGA APGSKADKDW VEVWKNSSER AAVREELATM
KADLLAKDRS ETSPTAWAEF AMPIWYQFCV ILRRNFQQFW RTPDYIYAKL VMSIMPTLFI
GFSFWRAGTS IQGLENQTFA IFMFLTMFPN LSQQMMPYFA LQRSLYEVRE RPSKAYSWKA
FILAAIVVEI PWNLFIAVPA FLAWYYPIGL YENAEPTNSV VSRGGTMFLI ILLFMLFTST
FTMMVIAGIE DVAAAGQISQ LLFSLCLVFC GVLVTPNALP GFWIFMYRVS PFTYMVSAVL
SVGLAQTAVQ CSSIELLSLA PPNAGETCQS FLGSYVSSAG GQLMNPNATS NCEYCSLATT
DEFLAAEGIY FSDRWRNIGI LFAYCGFNIL AAVFLYWLAR VPKGNRVKEV PDARNAPLAQ
SESAKELKEG K
//
